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Figure 2 | Veterinary Research

Figure 2

From: Previous infection with virulent strains of Newcastle disease virus reduces highly pathogenic avian influenza virus replication, disease, and mortality in chickens

Figure 2

Immunohistochemical staining for NDV and HPAIV antigens in tissues of co-infected chickens. Viral antigens are stained red. Spleen and lung from a chicken sequentially inoculated with a low virulence lNDV (LaSota strain) and a HPAIV (A/Ck/Queretaro/14588-19/95 H5N2); tissues collected 2 days after HPAIV inoculation (A and B, lung; C and D spleen). Strong virus staining for HPAIV (A and C) but not for NDV (B and D). HPAIV antigen staining found in epithelium of air capillaries, mononuclear cells and necrotic debris in lungs, and in mononuclear cells and necrotic debris in spleen. Spleen and lung from a chicken sequentially inoculated with a virulent vNDV (CA2002 strain) and a HPAIV (A/Ck/Queretaro/14588-19/95 H5N2); tissues collected 2 days after HPAIV inoculation (E and F, lung; G and H spleen). Strong antigen staining for NDV (F and H) but not for HPAIV (E and G). NDV antigen staining found in mononuclear cells and necrotic debris in lung and in the histiocytes surrounding the penicillary arteries in spleen. Magnifications, 400X.

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Veterinary Research

ISSN: 1297-9716