Figure 4

Distribution of estimated parameters characterizing kinetics of the MAP-specific cellular immune response. We fitted a simple “T _on-T _off” model to the experimental LPT data (fits are shown in Figure 3) and plotted the distribution of estimated parameters. Shown parameters are the rate of expansion of the immune response over time ρ _C (panel A), the time of the predicted peak of the immune response T ^C_off (panel B), and the rate of decline of the immune response after the peak δ _C (panel C; see Additional file 2 for the list of parameter estimates and their 95% confidence intervals).