Gene expression in the chicken caecum in response to infections with non-typhoid Salmonella

Rychlik, Ivan; Elsheimer-Matulova, Marta; Kyrova, Kamila

doi:10.1186/s13567-014-0119-2

Veterinary Research

Table 1 List of genes induced or suppressed in the chicken caecum 4 days after infection of newly hatched chickens with Salmonella Enteritidis

From: Gene expression in the chicken caecum in response to infections with non-typhoid Salmonella

Gene	Name	Function	Cell	Protein	RNA	Ref.
GENES UPREGULATED IN THE CHICKEN CECUM
MMP7	matrix metallopeptidase 7	degradation of extracellular matrix proteins	Ep	ND	1430.8	[12]
MUC2L	mucin-2-like	mucus production	Ep	ND	4.02	[12]
IFIT5	interferon-induced protein with tetratricopeptide repeats 5	uncapped RNA binding and inactivation	unknown	ND	6.75	[12]
ES1	ES1 protein homolog	unknown	unknown	25.8	28.30	[12]
IL8	interleukin 8	chemokine	Ep, M	ND	5.36	[12]
iNOS	inducible NO synthase	NO radical production using arginine as a substrate	M, T, B	ND	37.09	[12]
ExFABP	extracellular fatty acid binding protein	fatty acid and bacterial siderophore binding	Ht, M	ND	151.6	[12]
MRP126	MRP-126, S100A9, calprotectin, calgranulin	calcium and zinc binding	Ht, M	312	42.57	[12]
SERPINB10	serpin peptidase inhibitor	protection of tissues against own proteases	Ht, M	1313	30.95	[12]
TRAP6	trappin 6-like	protection of tissues against own proteases	Ht, M	ND	36.46	[37]
IRG1	immune responsive gene 1	itaconic acid and reactive oxygen species production	Ht, M	ND	83.17	[37]
SAA	serum amyloid A	acute phase protein, LPS binding	Ht, M	ND	84.63	[37]
C1QA	complement C1a component	complement	Ht, M	ND	3.23	[37]
C1QB	complement C1b component	complement	Ht, M	ND	1.28	[37]
C1QC	complement C1c component	complement	Ht, M	ND	3.00	[37]
C3	complement 3	complement	Ht, M	81.4	10.78	[12]
AVD	avidin	biotin binding, tissue reparation	M	ND	15.15	[37]
ASL2	argininosuccinate lyase	arginine recycling	M	12.2	4.36	[12]
IL1B	interleukin 1 β	cytokine	M	ND	28.09	[12],[32],[38]
IL18	interleukin 18	cytokine	M	ND	5.39	[32],[38]
CATHL2	cathelicidin-2	antimicrobial peptide	Ht	317	2.15	[12]
CATHL3	cathelicidin-3	antimicrobial peptide	Ht	ND	1.50	[12]
GAL1	gallinacin-1	antimicrobial peptide	Ht	ND	0.70	[32]
GAL2	gallinacin-2	antimicrobial peptide	Ht	ND	1.22	[32]
LYG2L	lysozyme G-like 2	antimicrobial peptide	Ht	283	37.21	[12]
PGDS	prostaglandin D2 synthase	prostaglandin D2 synthesis	Ht	ND	10.42	[12]
RSFR	leukocyte ribonuclease A-2	angiogenesis, antimicrobial peptide, ribonuclease	Ht	915	5.70	[12]
TGM3	transglutaminase 3	protein cross-linking	Ht	643	2.76	[12]
IgY	immunoglobulin Y heavy chain	antigen binding	B	ND	8.51	[37]
IgA	immunoglobulin A heavy chain	antigen binding	B	ND	3.50	[37]
IgM	immunoglobulin M heavy chain	antigen binding	B	ND	3.91	[37]
IgL	immunoglobulin light chain	antigen binding	B	ND	7.09	[37]
TGM4	glutamine γ-glutamyltransferase 4	protein crosslinking	B, M	484	24.63	[12]
IL17	interleukin 17	cytokine	T	ND	5.43	[12],[32],[38]
IL22	interleukin 22	cytokine	T	ND	63.18	[12],[32],[38]
IFNG	interferon γ	cytokine	T	ND	32.08	[12],[32],[38]
NKL	NK-lysin	lysis of own aberant cells	T	ND	16.73	unpubl.
GENES DOWNREGULATED IN THE CHICKEN CAECUM
HPGD	hydroxyprostaglandin dehydrogenase 15-(NAD)	inactivation of prostaglandin D2	unknown	ND	4.0	[12]
LOC769608	uncharacterized oxidoreductase	unknown	unknown	2.77	4.3	[12]
ALDOB	aldolase B, fructose-bisphosphate	unknown	unknown	2.64	4.6	[12]
CALB1	calbindin 1	calcium transport	Ep	2.26	5.5	[12]
SULT1C3	sulfotransferase	solubilasation and detoxification	unknown	ND	6.2	[12]
RALDH1	aldehyde dehydrogenase 1	unknown	unknown	2.74	7.9	[12]
FABP1	fatty acid binding protein 1	fatty acid transport	Ep	2.92	8.3	[12]
AQP8	aquaporin 8	water, ammonia and hydrogen peroxide transport	Ep	ND	9.9	[12]
ADH1B	alcohol dehydrogenase 1B	unknown	unknown	4.52	13.2	[12]

Ep, epithelial cell, Ht – heterophil, M – macrophage, B – B lymphocyte, T – T lymphocyte, protein – fold induction or suppression determined by protein mass spectrometry, RNA – fold induction or suppression determined by real-time PCR, ND – not determined.

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