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Table 1 List of genes induced or suppressed in the chicken caecum 4 days after infection of newly hatched chickens with Salmonella Enteritidis

From: Gene expression in the chicken caecum in response to infections with non-typhoid Salmonella

Gene Name Function Cell Protein RNA Ref.
GENES UPREGULATED IN THE CHICKEN CECUM
MMP7 matrix metallopeptidase 7 degradation of extracellular matrix proteins Ep ND 1430.8 [12]
MUC2L mucin-2-like mucus production Ep ND 4.02 [12]
IFIT5 interferon-induced protein with tetratricopeptide repeats 5 uncapped RNA binding and inactivation unknown ND 6.75 [12]
ES1 ES1 protein homolog unknown unknown 25.8 28.30 [12]
IL8 interleukin 8 chemokine Ep, M ND 5.36 [12]
iNOS inducible NO synthase NO radical production using arginine as a substrate M, T, B ND 37.09 [12]
ExFABP extracellular fatty acid binding protein fatty acid and bacterial siderophore binding Ht, M ND 151.6 [12]
MRP126 MRP-126, S100A9, calprotectin, calgranulin calcium and zinc binding Ht, M 312 42.57 [12]
SERPINB10 serpin peptidase inhibitor protection of tissues against own proteases Ht, M 1313 30.95 [12]
TRAP6 trappin 6-like protection of tissues against own proteases Ht, M ND 36.46 [37]
IRG1 immune responsive gene 1 itaconic acid and reactive oxygen species production Ht, M ND 83.17 [37]
SAA serum amyloid A acute phase protein, LPS binding Ht, M ND 84.63 [37]
C1QA complement C1a component complement Ht, M ND 3.23 [37]
C1QB complement C1b component complement Ht, M ND 1.28 [37]
C1QC complement C1c component complement Ht, M ND 3.00 [37]
C3 complement 3 complement Ht, M 81.4 10.78 [12]
AVD avidin biotin binding, tissue reparation M ND 15.15 [37]
ASL2 argininosuccinate lyase arginine recycling M 12.2 4.36 [12]
IL1B interleukin 1 β cytokine M ND 28.09 [12],[32],[38]
IL18 interleukin 18 cytokine M ND 5.39 [32],[38]
CATHL2 cathelicidin-2 antimicrobial peptide Ht 317 2.15 [12]
CATHL3 cathelicidin-3 antimicrobial peptide Ht ND 1.50 [12]
GAL1 gallinacin-1 antimicrobial peptide Ht ND 0.70 [32]
GAL2 gallinacin-2 antimicrobial peptide Ht ND 1.22 [32]
LYG2L lysozyme G-like 2 antimicrobial peptide Ht 283 37.21 [12]
PGDS prostaglandin D2 synthase prostaglandin D2 synthesis Ht ND 10.42 [12]
RSFR leukocyte ribonuclease A-2 angiogenesis, antimicrobial peptide, ribonuclease Ht 915 5.70 [12]
TGM3 transglutaminase 3 protein cross-linking Ht 643 2.76 [12]
IgY immunoglobulin Y heavy chain antigen binding B ND 8.51 [37]
IgA immunoglobulin A heavy chain antigen binding B ND 3.50 [37]
IgM immunoglobulin M heavy chain antigen binding B ND 3.91 [37]
IgL immunoglobulin light chain antigen binding B ND 7.09 [37]
TGM4 glutamine γ-glutamyltransferase 4 protein crosslinking B, M 484 24.63 [12]
IL17 interleukin 17 cytokine T ND 5.43 [12],[32],[38]
IL22 interleukin 22 cytokine T ND 63.18 [12],[32],[38]
IFNG interferon γ cytokine T ND 32.08 [12],[32],[38]
NKL NK-lysin lysis of own aberant cells T ND 16.73 unpubl.
GENES DOWNREGULATED IN THE CHICKEN CAECUM
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) inactivation of prostaglandin D2 unknown ND 4.0 [12]
LOC769608 uncharacterized oxidoreductase unknown unknown 2.77 4.3 [12]
ALDOB aldolase B, fructose-bisphosphate unknown unknown 2.64 4.6 [12]
CALB1 calbindin 1 calcium transport Ep 2.26 5.5 [12]
SULT1C3 sulfotransferase solubilasation and detoxification unknown ND 6.2 [12]
RALDH1 aldehyde dehydrogenase 1 unknown unknown 2.74 7.9 [12]
FABP1 fatty acid binding protein 1 fatty acid transport Ep 2.92 8.3 [12]
AQP8 aquaporin 8 water, ammonia and hydrogen peroxide transport Ep ND 9.9 [12]
ADH1B alcohol dehydrogenase 1B unknown unknown 4.52 13.2 [12]
  1. Ep, epithelial cell, Ht – heterophil, M – macrophage, B – B lymphocyte, T – T lymphocyte, protein – fold induction or suppression determined by protein mass spectrometry, RNA – fold induction or suppression determined by real-time PCR, ND – not determined.