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Table 1 Morbidity, mortality, and serological data from ferrets fed different quantities of H5N1 HPAIV in infected chicken meat to determine ferret mean infectious (FID 50 ) and lethal (FLD 50 ) doses

From: High doses of highly pathogenic avian influenza virus in chicken meat are required to infect ferrets

Virus group, dose (EID50) Morbidity Mortality Neutralizing antibody titers (14 dpc)* ID50/LD50(log10EID50/0.1 mL)
Mong/05     4.9/>9.2
  Low (104.2) 0/3 0/3 1/3 (113)  
  Medium (106.8) 1/3 0/3 3/3 (35, 226, 453)  
  High (109.2) 1/3 0/3 3/3 (320, 453, 2560)  
VN/04     7.5/8.9
  Low (104.3) 0/3 0/3 0/3  
  Medium (106.9) 0/3 0/3 1/3 (226)  
  High (109.6) 3/3 2/3 1/1 (394)  
  1. dpc, days post-challenge; Mong/05, A/Whooper swan/Mongolia/244/05; VN/04, A/Vietnam/1203/04.
  2. *Number positive/total of ferrets that seroconverted at 14 dpc based on virus neutralization (VN). In parenthesis, individual neutralizing antibody titers (<20 were considered negative).
  3. ID50, mean infectious dose; based on seroconversion by VN.
  4. LD50, mean lethal dose; based on mortality.