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Table 1 Morbidity, mortality, and serological data from ferrets fed different quantities of H5N1 HPAIV in infected chicken meat to determine ferret mean infectious (FID 50 ) and lethal (FLD 50 ) doses

From: High doses of highly pathogenic avian influenza virus in chicken meat are required to infect ferrets

Virus group, dose (EID50)

Morbidity

Mortality

Neutralizing antibody titers (14 dpc)*

ID50†/LD50‡(log10EID50/0.1 mL)

Mong/05

   

4.9/>9.2

  Low (104.2)

0/3

0/3

1/3 (113)

 

  Medium (106.8)

1/3

0/3

3/3 (35, 226, 453)

 

  High (109.2)

1/3

0/3

3/3 (320, 453, 2560)

 

VN/04

   

7.5/8.9

  Low (104.3)

0/3

0/3

0/3

 

  Medium (106.9)

0/3

0/3

1/3 (226)

 

  High (109.6)

3/3

2/3

1/1 (394)

 
  1. dpc, days post-challenge; Mong/05, A/Whooper swan/Mongolia/244/05; VN/04, A/Vietnam/1203/04.
  2. *Number positive/total of ferrets that seroconverted at 14 dpc based on virus neutralization (VN). In parenthesis, individual neutralizing antibody titers (<20 were considered negative).
  3. †ID50, mean infectious dose; based on seroconversion by VN.
  4. ‡LD50, mean lethal dose; based on mortality.
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Veterinary Research

ISSN: 1297-9716