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Table 1 Cellular markers of chicken skin

From: Marek’s disease virus and skin interactions

Cell layers of the skin Cellular markers Functions
Dermis Fibronectin Glycoprotein which contributes to extracellular matrix organization and favors cell adherence
Basal membrane Laminin Protein complex, an essential component from the basal membrane, which constitutes a molecular filter
Basal layer of epidermis Basonuclin 2 Nuclear protein with zinc fingers, transcription factor which maintains the proliferative ability and prevents the terminal differentiation
Keratin 5 (KRT5) α-keratin type II, intermediate filament of proliferating keratinocytes, associated to KRT14
Keratin 14 (KRT14) α-keratin type I, intermediate filament of proliferating keratinocytes, associated to KRT5
Intermediate layer of epidermis Transglutaminase 5 Calcium dependent-enzyme involved in the first differentiation steps of the epidermis
Desmoglein 2 Cadherin playing a role in the formation of desmosomes, that connect together epithelial cells
Transitional layer of epidermis Keratin 75 (KRT 75) α-keratin type IIB, marker from the terminal differentiation of the keratinocytes
Keratin 10 (KRT10) α-keratin type I, marker from the terminal differentiation of the keratinocytes, associated to keratin 1
Cornified layer of epidermis Involucrin Precursor protein from the corneocyte envelope
Filaggrin Basic protein associated to keratin filaments of the cornified layer
Loricrin Precursor protein from the corneocyte envelope