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Table 2 The 39 differentially expressed genes (adjusted p -value < 0.05 and fold change > 1.5) in Milk Fat Globules of goats ( n= 5), in response to an experimental IMI with S. aureus, in at least one of the two pairwise comparisons (T0 vs. 12 hpi; 12 hpi vs. 18 hpi)

From: Contribution of mammary epithelial cells to the immune response during early stages of a bacterial infection to Staphylococcus aureus

Description Gene symbol Biological function Fold change T0/T12 (sens of regulation) Fold change T12/T18 (sens of regulation)
Arachidonate 5-lipoxygenase-activating protein ALOX5AP Leukotriene metabolic process 1.1 1.7 (up)
Bcl-2-related protein A1 BCL2A1 Apoptosis 1.0 5.1 (up)
Chemokine (C-C motif) ligand 2 CCL2 Inflammatory response, chemotaxis 1.6 (up) 1.6 (up)
Chemokine (C-C motif) ligand 4 CCL4 Inflammatory response, chemotaxis 1.1 6.8 (up)
C-type lectin domain family 4 member E CLEC4E Immune response 1.3 6.1 (up)
Cathepsin Z CTSZ Proteolysis 1.4 1.5 (up)
Early growth response protein 1 EGR1 Regulation of transcription, cell proliferation 1.1 1.6 (up)
Early growth response 3 EGR3 Apoptosis, chemotaxis 1.1 2.3 (up)
Fc fragment of IgG, low affinity IIIa, receptor FCGR3A Immune response 1.7 (down) 1.8 (up)
Proto-oncogene protein c-fos FOS Regulation of transcription, cell proliferation 1.1 2.5 (up)
Growth arrest and DNA-damage-inducible protein GADD45 alpha GADD45α Cell cycle 1.8 (down) 3.2 (up)
Immediate early response 3 IER3 Inflammatory response 1.5 (up) 2.7 (up)
Interleukin-18-binding protein Precursor IL18BP Regulation of transcription, cell proliferation 1.3 1.7 (down)
Interleukin 1 beta IL-1β Inflammatory response, cytokine biosynthesis 1.5 (down) 5.6 (up)
Interleukin-1 receptor IL1RN Inflammatory response 1.0 9.8 (up)
Interleukin-2 receptor gamma chain IL2RG Regulation of gene expression, alpha-beta Regulatory T cell differentiation 1.2 1.5 (up)
Interleukin 8 IL-8 Chemotaxis 1.3 8.5 (up)
Metallothionein-1A MT-1A Cellular response to zinc and cadmium ion 1.4 1.7 (down)
Phosphodiesterase 4B, cAMP-specific PDE4B Signal transduction 2.1 (up) 2.1 (up)
Platelet/endothelial cell adhesion molecule PECAM1 Cell adhesion 1.4 3.0 (up)
Pentraxin-related protein PTX3 Regulation of phagocytosis 1.2 4.8 (up)
Regulator of G-protein signaling 2 RGS2 Cell cycle 1.2 2.2 (up)
Ras-related associated with diabetes RRAD Protein transport 1.0 1.6 (up)
S100 calcium-binding protein A12 S100A12 Inflammatory response 1.9 (down) 8.0 (up)
Protein strawberry notch homolog 2 SBNO2 Regulation of transcription, cell proliferation 1.4 1.6 (down)
Serine dehydratase SDS Cellular amino acid metabolic process 1.3 5.7 (up)
Alpha-1-antitrypsin SERPINA1 Inflammatory response, acute phase response 1.3 2.1 (up)
Solute carrier family 2, facilitated glucose transporter member 3 SLC2A3 Carbohydrate transmembrane transport 1.4 6.9 (up)
Suppressor of cytokine signaling 3 SOCS3 Inflammatory response 1.4 2.4 (up)
Spleen focus forming virus (SFFV) proviral integration oncogene SPI1 Regulation of transcription, cell proliferation 2.7 (down) 4.4 (up)
Serglycin SRGN Apoptosis 1.3 8.4 (up)
Tumor necrosis factor alpha TNFα Inflammatory response, anti aptoptosis 1.3 2.9 (up)
Tumor necrosis factor alpha-induced protein 6 TNFAIP6 Cell adhesion 1.0 9.1 (up)
Tristetraprolin TTP Inflammatory response 1.0 1.6 (up)
Thioredoxin-interacting protein TXNIP Response to oxidative stress 2.1 (down) 1.5 (up)
021030OOCX008067HT OOCX Ovisaries cDNA    1,7 (up) 4.0 (up)
MGC165862 protein    1.6 (down) 3.4 (up)
020605OCS411016083HT OCS4 Ovisaries cDNA    1.2 21.0 (up)
Taste receptor type 2 – Bos taurus (Bovine), partial (26%) [TC17737]    1.5 (down) 2.7 (up)
  1. Adjusted p-value < 0.05 and fold change > 1.5 are in bold, in at least one of the two pairwise comparisons.