Table 2 The 39 differentially expressed genes (adjusted p -value < 0.05 and fold change > 1.5) in Milk Fat Globules of goats ( n = 5), in response to an experimental IMI with S. aureus, in at least one of the two pairwise comparisons (T0 vs. 12 hpi; 12 hpi vs. 18 hpi)
Description | Gene symbol | Biological function | Fold change T0/T12 (sens of regulation) | Fold change T12/T18 (sens of regulation) |
|---|---|---|---|---|
Arachidonate 5-lipoxygenase-activating protein | ALOX5AP | Leukotriene metabolic process | 1.1 | 1.7 (up) |
Bcl-2-related protein A1 | BCL2A1 | Apoptosis | 1.0 | 5.1 (up) |
Chemokine (C-C motif) ligand 2 | CCL2 | Inflammatory response, chemotaxis | 1.6 (up) | 1.6 (up) |
Chemokine (C-C motif) ligand 4 | CCL4 | Inflammatory response, chemotaxis | 1.1 | 6.8 (up) |
C-type lectin domain family 4 member E | CLEC4E | Immune response | 1.3 | 6.1 (up) |
Cathepsin Z | CTSZ | Proteolysis | 1.4 | 1.5 (up) |
Early growth response protein 1 | EGR1 | Regulation of transcription, cell proliferation | 1.1 | 1.6 (up) |
Early growth response 3 | EGR3 | Apoptosis, chemotaxis | 1.1 | 2.3 (up) |
Fc fragment of IgG, low affinity IIIa, receptor | FCGR3A | Immune response | 1.7 (down) | 1.8 (up) |
Proto-oncogene protein c-fos | FOS | Regulation of transcription, cell proliferation | 1.1 | 2.5 (up) |
Growth arrest and DNA-damage-inducible protein GADD45 alpha | GADD45α | Cell cycle | 1.8 (down) | 3.2 (up) |
Immediate early response 3 | IER3 | Inflammatory response | 1.5 (up) | 2.7 (up) |
Interleukin-18-binding protein Precursor | IL18BP | Regulation of transcription, cell proliferation | 1.3 | 1.7 (down) |
Interleukin 1 beta | IL-1β | Inflammatory response, cytokine biosynthesis | 1.5 (down) | 5.6 (up) |
Interleukin-1 receptor | IL1RN | Inflammatory response | 1.0 | 9.8 (up) |
Interleukin-2 receptor gamma chain | IL2RG | Regulation of gene expression, alpha-beta Regulatory T cell differentiation | 1.2 | 1.5 (up) |
Interleukin 8 | IL-8 | Chemotaxis | 1.3 | 8.5 (up) |
Metallothionein-1A | MT-1A | Cellular response to zinc and cadmium ion | 1.4 | 1.7 (down) |
Phosphodiesterase 4B, cAMP-specific | PDE4B | Signal transduction | 2.1 (up) | 2.1 (up) |
Platelet/endothelial cell adhesion molecule | PECAM1 | Cell adhesion | 1.4 | 3.0 (up) |
Pentraxin-related protein | PTX3 | Regulation of phagocytosis | 1.2 | 4.8 (up) |
Regulator of G-protein signaling 2 | RGS2 | Cell cycle | 1.2 | 2.2 (up) |
Ras-related associated with diabetes | RRAD | Protein transport | 1.0 | 1.6 (up) |
S100 calcium-binding protein A12 | S100A12 | Inflammatory response | 1.9 (down) | 8.0 (up) |
Protein strawberry notch homolog 2 | SBNO2 | Regulation of transcription, cell proliferation | 1.4 | 1.6 (down) |
Serine dehydratase | SDS | Cellular amino acid metabolic process | 1.3 | 5.7 (up) |
Alpha-1-antitrypsin | SERPINA1 | Inflammatory response, acute phase response | 1.3 | 2.1 (up) |
Solute carrier family 2, facilitated glucose transporter member 3 | SLC2A3 | Carbohydrate transmembrane transport | 1.4 | 6.9 (up) |
Suppressor of cytokine signaling 3 | SOCS3 | Inflammatory response | 1.4 | 2.4 (up) |
Spleen focus forming virus (SFFV) proviral integration oncogene | SPI1 | Regulation of transcription, cell proliferation | 2.7 (down) | 4.4 (up) |
Serglycin | SRGN | Apoptosis | 1.3 | 8.4 (up) |
Tumor necrosis factor alpha | TNFα | Inflammatory response, anti aptoptosis | 1.3 | 2.9 (up) |
Tumor necrosis factor alpha-induced protein 6 | TNFAIP6 | Cell adhesion | 1.0 | 9.1 (up) |
Tristetraprolin | TTP | Inflammatory response | 1.0 | 1.6 (up) |
Thioredoxin-interacting protein | TXNIP | Response to oxidative stress | 2.1 (down) | 1.5 (up) |
021030OOCX008067HT OOCX Ovisaries cDNA | Â | Â | 1,7 (up) | 4.0 (up) |
MGC165862 protein | Â | Â | 1.6 (down) | 3.4 (up) |
020605OCS411016083HT OCS4 Ovisaries cDNA | Â | Â | 1.2 | 21.0 (up) |
Taste receptor type 2 – Bos taurus (Bovine), partial (26%) [TC17737] |  |  | 1.5 (down) | 2.7 (up) |