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Table 2 The 39 differentially expressed genes (adjusted p -value < 0.05 and fold change > 1.5) in Milk Fat Globules of goats ( n = 5), in response to an experimental IMI with S. aureus, in at least one of the two pairwise comparisons (T0 vs. 12 hpi; 12 hpi vs. 18 hpi)
| Description | Gene symbol | Biological function | Fold change T0/T12 (sens of regulation) | Fold change T12/T18 (sens of regulation) |
|---|---|---|---|---|
| Arachidonate 5-lipoxygenase-activating protein | ALOX5AP | Leukotriene metabolic process | 1.1 | 1.7 (up) |
| Bcl-2-related protein A1 | BCL2A1 | Apoptosis | 1.0 | 5.1 (up) |
| Chemokine (C-C motif) ligand 2 | CCL2 | Inflammatory response, chemotaxis | 1.6 (up) | 1.6 (up) |
| Chemokine (C-C motif) ligand 4 | CCL4 | Inflammatory response, chemotaxis | 1.1 | 6.8 (up) |
| C-type lectin domain family 4 member E | CLEC4E | Immune response | 1.3 | 6.1 (up) |
| Cathepsin Z | CTSZ | Proteolysis | 1.4 | 1.5 (up) |
| Early growth response protein 1 | EGR1 | Regulation of transcription, cell proliferation | 1.1 | 1.6 (up) |
| Early growth response 3 | EGR3 | Apoptosis, chemotaxis | 1.1 | 2.3 (up) |
| Fc fragment of IgG, low affinity IIIa, receptor | FCGR3A | Immune response | 1.7 (down) | 1.8 (up) |
| Proto-oncogene protein c-fos | FOS | Regulation of transcription, cell proliferation | 1.1 | 2.5 (up) |
| Growth arrest and DNA-damage-inducible protein GADD45 alpha | GADD45α | Cell cycle | 1.8 (down) | 3.2 (up) |
| Immediate early response 3 | IER3 | Inflammatory response | 1.5 (up) | 2.7 (up) |
| Interleukin-18-binding protein Precursor | IL18BP | Regulation of transcription, cell proliferation | 1.3 | 1.7 (down) |
| Interleukin 1 beta | IL-1β | Inflammatory response, cytokine biosynthesis | 1.5 (down) | 5.6 (up) |
| Interleukin-1 receptor | IL1RN | Inflammatory response | 1.0 | 9.8 (up) |
| Interleukin-2 receptor gamma chain | IL2RG | Regulation of gene expression, alpha-beta Regulatory T cell differentiation | 1.2 | 1.5 (up) |
| Interleukin 8 | IL-8 | Chemotaxis | 1.3 | 8.5 (up) |
| Metallothionein-1A | MT-1A | Cellular response to zinc and cadmium ion | 1.4 | 1.7 (down) |
| Phosphodiesterase 4B, cAMP-specific | PDE4B | Signal transduction | 2.1 (up) | 2.1 (up) |
| Platelet/endothelial cell adhesion molecule | PECAM1 | Cell adhesion | 1.4 | 3.0 (up) |
| Pentraxin-related protein | PTX3 | Regulation of phagocytosis | 1.2 | 4.8 (up) |
| Regulator of G-protein signaling 2 | RGS2 | Cell cycle | 1.2 | 2.2 (up) |
| Ras-related associated with diabetes | RRAD | Protein transport | 1.0 | 1.6 (up) |
| S100 calcium-binding protein A12 | S100A12 | Inflammatory response | 1.9 (down) | 8.0 (up) |
| Protein strawberry notch homolog 2 | SBNO2 | Regulation of transcription, cell proliferation | 1.4 | 1.6 (down) |
| Serine dehydratase | SDS | Cellular amino acid metabolic process | 1.3 | 5.7 (up) |
| Alpha-1-antitrypsin | SERPINA1 | Inflammatory response, acute phase response | 1.3 | 2.1 (up) |
| Solute carrier family 2, facilitated glucose transporter member 3 | SLC2A3 | Carbohydrate transmembrane transport | 1.4 | 6.9 (up) |
| Suppressor of cytokine signaling 3 | SOCS3 | Inflammatory response | 1.4 | 2.4 (up) |
| Spleen focus forming virus (SFFV) proviral integration oncogene | SPI1 | Regulation of transcription, cell proliferation | 2.7 (down) | 4.4 (up) |
| Serglycin | SRGN | Apoptosis | 1.3 | 8.4 (up) |
| Tumor necrosis factor alpha | TNFα | Inflammatory response, anti aptoptosis | 1.3 | 2.9 (up) |
| Tumor necrosis factor alpha-induced protein 6 | TNFAIP6 | Cell adhesion | 1.0 | 9.1 (up) |
| Tristetraprolin | TTP | Inflammatory response | 1.0 | 1.6 (up) |
| Thioredoxin-interacting protein | TXNIP | Response to oxidative stress | 2.1 (down) | 1.5 (up) |
| 021030OOCX008067HT OOCX Ovisaries cDNA | 1,7 (up) | 4.0 (up) | ||
| MGC165862 protein | 1.6 (down) | 3.4 (up) | ||
| 020605OCS411016083HT OCS4 Ovisaries cDNA | 1.2 | 21.0 (up) | ||
| Taste receptor type 2 – Bos taurus (Bovine), partial (26%) [TC17737] | 1.5 (down) | 2.7 (up) |
