Table 4 Top bio functions identified by ingenuity pathway analysis, from the Affymetrix ovine gene array.

Immunological Disease

CSF3R, SELE, PTGDR2, IL1RL1, IGHE, VIPR2, CCL23, NR1H4, IL13RA2, CCL17, CCL22, IL13, ADRA1D, HRH1, IL17RB, CCR4, CCL2, NLRP12, CD1A, CCL26, CFH,HRH4, CYSLTR2, FCER2.

2.73 × 10^-13 - 6.71 × 10^-03

Inflammatory Response

GATA1, CRLF2, NR1H4, VIPR2, IL1RL1, IL13RA2, SOCS2, P2RX1, CCL17, SLC9A4, CCL22, HRH1, NFIL, TFF2, CCL2, CD1A, HPGD, CFH, CYSLTR2, FCER2, CSF3R, ALOX15, SELE, PTGDR2, IL5RA, CCL23, IGHE, CD200R1, CD1B, ULBP1, P2RX7, IL13, IL17RB, CCR4, NT5E, NLRP12, PILRA, CCL26, IGHA1, SH2D1B, HRH4.

8.34 × 10^-13 - 6.71 × 10^-03

Hypersensitivity Response

ALOX15, PTGDR2, SELE, IL5RA, GATA1, VIPR2, IL1RL1, IGHE, CD200R1, CCL17, CCL22, P2RX7, IL13, IL17RB, CCR4, CCL2, CCL26, HRH4, FCER2

7.98 × 10^-11 - 4.94 × 10^-03

Dermatological Diseases and Conditions

ALOX15, PTGDR2, SELE, IGHE, VIPR2, NR1H4, CCL23, CCL17, CCL22, IL13, ADRA1D, HRH1, IL17RB, CCL2, CCR4, NT5E, CD1A, HPGD, HRH4, CYSLTR2, FCER2

1.78 × 10^-09 - 6.71 × 10^-03

Inflammatory Disease

CRLF2, NR1H4, IL1RL1, VIPR2, IL13RA2, CCL17, CCL22, HRH1, TH, COL6A1, CCL2, CD1A, HPGD, CFH, CYSLTR2, FCER2, CSF3R, ALOX15, SELE, PTGDR2, IL5RA, CCL23, IGHE, CD200R1, P2RX7, IL13, ADRA1D, GLIPR2, IL17RB, CCR4, NT5E, NLRP12, CCL26.

1.78 × 10^-09 - 5.7 × 10^-03

PHYSIOLOGICAL SYSTEM DEVELOPMENT AND FUNCTION

P -value

Haematological System Development and Function

GATA1, CRLF2, VIPR2, IL1RL1, SOCS2, IL13RA2, P2RX1, CCL17, CCL22, HRH1, NFIL3, TFF2, CCL2, CD1A, CFH, CYSLTR2, FCER2, CSF3R, ALOX15, PTGDR2, SELE, IL5RA, IGHE, CCL23, CD200R1, CD1B, ULBP1, P2RX7, IL13, ZBTB32, IL17RB, CCR4, NLRP12, NT5E, MYOCD, CCL26, CYP4A11.

4.79 × 10^-12 - 6.71 × 10^-03

Tissue Morphology

GATA1, CRLF2, VIPR2, IL1RL1, NR1H4, IL13RA2, SLC9A4, CCL22, TH, HRH1, NFIL3,TFF2, CCL2, CFH, SMPD3, FCER2, CSF3R, ALOX15, SELE, PTGDR2, IL5RA, IGHE, CD200R1, P2RX, IL13, OXT, IL17RB, CCR4, NLRP12, NT5E, FLNC, CNN1, CYP4A11.

4.79 × 10^-12 - 6.49 × 10^-03

Humoral Immune Response

HRH1,PTGDR2, NFIL3, IL5RA, IL17RB, CRLF2, CCR4, IGHE, IL1RL1, IL13RA2, IL13, HRH4, FCER2.

2.28 × 10^-11 - 6.53 × 10^-03

Immune Cell Trafficking

IL1RL1, VIPR2, SOCS2, CCL17, CCL22, HRH1, NFIL3, TFF2, CCL2, CD1A, CFH, CYSLTR2, FCER2, CSF3R, ALOX15, PTGDR2, SELE, IGHE, CCL23, CD200R1, ULBP1, CD1B, P2RX7, IL13, IL17RB, CCR4, NT5E, NLRP12, CCL26.

5.04 × 10^-10 - 6.71 × 10^-03

Cell-mediated Immune Response

PTGDR2, SELE, GATA1, CCR4, CCL2, IL1RL1, CCL23, IL13RA2, CCL17, CCL22, IL13.

1.09 × 10^-08 - 5.63 × 10^-03

Lymphoid Tissue Structure and Development

CSF3R, ALOX15, SELE, GATA1, CRLF2, IL1RL1, IL13RA2, CCL17, CCL22, P2RX7, IL13, CCL2, CCR4, NT5E, CYSLTR2

3.82 × 10^-07 - 5.7 × 10^-03

Digestive System Development and Function

TFF2, NR1H4, IL13RA2, SLC9A4, IL13

2.41 × 10^-05 - 4.94 × 10^-03

DISEASES AND DISORDERS

P -value

Hypersensitivity Response

FCER2, IGHE, SELE, VIPR2.

1.76 × 10^-06 - 3.31 × 10^-02

Inflammatory Disease

FCER2, IGHE, IGKC, NT5E, SELE, VIPR2

4.64 × 10^-05 - 4.10 × 10^-02

PHYSIOLOGICAL SYSTEM DEVELOPMENT AND FUNCTION

P -value

Hematological System Development and Function

FCER2, IGHE, IGKC, SELE, NT5E, VIPR2.

1.76 × 10^-06 - 4.57 × 10^-02

Immune Cell Trafficking

FCER2, IGHE, NT5E, SELE, VIPR2.

1.76 × 10^-06 - 4.57 × 10^-02

DISEASES AND DISORDERS

P -value

Gastrointestinal Disease

CCL26, IL13.

9.85 × 10^-06 - 2.62 × 10^-02

Hematological Disease

CCL26, CD1A, IL13, FCER2, IGHE, IGKC, NT5E, SELE, VIPR2.

9.85 × 10^-06 - 2.62 × 10^-02

PHYSIOLOGICAL SYSTEM DEVELOPMENT AND FUNCTION

P-value

Hematological System Development and Function

CCL26, CD1A, IL13.

2.35 × 10^-05 - 4.76 × 10^-02

Immune Cell Trafficking

CCL26, CD1A, IL13.

2.35 × 10^-05 - 4.76 × 10^-02