Skip to main content

Table 4 Top bio functions identified by ingenuity pathway analysis, from the Affymetrix ovine gene array.

From: Exploring the abomasal lymph node transcriptome for genes associated with resistance to the sheep nematode Teladorsagia circumcincta

a. R vs. C comparison
DISEASES AND DISORDERS P-value
Immunological Disease  
CSF3R, SELE, PTGDR2, IL1RL1, IGHE, VIPR2, CCL23, NR1H4, IL13RA2, CCL17, CCL22, IL13, ADRA1D, HRH1, IL17RB, CCR4, CCL2, NLRP12, CD1A, CCL26, CFH,HRH4, CYSLTR2, FCER2. 2.73 × 10-13 - 6.71 × 10-03
Inflammatory Response  
GATA1, CRLF2, NR1H4, VIPR2, IL1RL1, IL13RA2, SOCS2, P2RX1, CCL17, SLC9A4, CCL22, HRH1, NFIL, TFF2, CCL2, CD1A, HPGD, CFH, CYSLTR2, FCER2, CSF3R, ALOX15, SELE, PTGDR2, IL5RA, CCL23, IGHE, CD200R1, CD1B, ULBP1, P2RX7, IL13, IL17RB, CCR4, NT5E, NLRP12, PILRA, CCL26, IGHA1, SH2D1B, HRH4. 8.34 × 10-13 - 6.71 × 10-03
Hypersensitivity Response  
ALOX15, PTGDR2, SELE, IL5RA, GATA1, VIPR2, IL1RL1, IGHE, CD200R1, CCL17, CCL22, P2RX7, IL13, IL17RB, CCR4, CCL2, CCL26, HRH4, FCER2 7.98 × 10-11 - 4.94 × 10-03
Dermatological Diseases and Conditions  
ALOX15, PTGDR2, SELE, IGHE, VIPR2, NR1H4, CCL23, CCL17, CCL22, IL13, ADRA1D, HRH1, IL17RB, CCL2, CCR4, NT5E, CD1A, HPGD, HRH4, CYSLTR2, FCER2 1.78 × 10-09 - 6.71 × 10-03
Inflammatory Disease  
CRLF2, NR1H4, IL1RL1, VIPR2, IL13RA2, CCL17, CCL22, HRH1, TH, COL6A1, CCL2, CD1A, HPGD, CFH, CYSLTR2, FCER2, CSF3R, ALOX15, SELE, PTGDR2, IL5RA, CCL23, IGHE, CD200R1, P2RX7, IL13, ADRA1D, GLIPR2, IL17RB, CCR4, NT5E, NLRP12, CCL26. 1.78 × 10-09 - 5.7 × 10-03
PHYSIOLOGICAL SYSTEM DEVELOPMENT AND FUNCTION P -value
Haematological System Development and Function  
GATA1, CRLF2, VIPR2, IL1RL1, SOCS2, IL13RA2, P2RX1, CCL17, CCL22, HRH1, NFIL3, TFF2, CCL2, CD1A, CFH, CYSLTR2, FCER2, CSF3R, ALOX15, PTGDR2, SELE, IL5RA, IGHE, CCL23, CD200R1, CD1B, ULBP1, P2RX7, IL13, ZBTB32, IL17RB, CCR4, NLRP12, NT5E, MYOCD, CCL26, CYP4A11. 4.79 × 10-12 - 6.71 × 10-03
Tissue Morphology  
GATA1, CRLF2, VIPR2, IL1RL1, NR1H4, IL13RA2, SLC9A4, CCL22, TH, HRH1, NFIL3,TFF2, CCL2, CFH, SMPD3, FCER2, CSF3R, ALOX15, SELE, PTGDR2, IL5RA, IGHE, CD200R1, P2RX, IL13, OXT, IL17RB, CCR4, NLRP12, NT5E, FLNC, CNN1, CYP4A11. 4.79 × 10-12 - 6.49 × 10-03
Humoral Immune Response  
HRH1,PTGDR2, NFIL3, IL5RA, IL17RB, CRLF2, CCR4, IGHE, IL1RL1, IL13RA2, IL13, HRH4, FCER2. 2.28 × 10-11 - 6.53 × 10-03
Immune Cell Trafficking  
IL1RL1, VIPR2, SOCS2, CCL17, CCL22, HRH1, NFIL3, TFF2, CCL2, CD1A, CFH, CYSLTR2, FCER2, CSF3R, ALOX15, PTGDR2, SELE, IGHE, CCL23, CD200R1, ULBP1, CD1B, P2RX7, IL13, IL17RB, CCR4, NT5E, NLRP12, CCL26. 5.04 × 10-10 - 6.71 × 10-03
Cell-mediated Immune Response  
PTGDR2, SELE, GATA1, CCR4, CCL2, IL1RL1, CCL23, IL13RA2, CCL17, CCL22, IL13. 1.09 × 10-08 - 5.63 × 10-03
Lymphoid Tissue Structure and Development  
CSF3R, ALOX15, SELE, GATA1, CRLF2, IL1RL1, IL13RA2, CCL17, CCL22, P2RX7, IL13, CCL2, CCR4, NT5E, CYSLTR2 3.82 × 10-07 - 5.7 × 10-03
Digestive System Development and Function  
TFF2, NR1H4, IL13RA2, SLC9A4, IL13 2.41 × 10-05 - 4.94 × 10-03
b. S vs. C comparison
DISEASES AND DISORDERS P -value
Hypersensitivity Response  
FCER2, IGHE, SELE, VIPR2. 1.76 × 10-06 - 3.31 × 10-02
Inflammatory Disease  
FCER2, IGHE, IGKC, NT5E, SELE, VIPR2 4.64 × 10-05 - 4.10 × 10-02
PHYSIOLOGICAL SYSTEM DEVELOPMENT AND FUNCTION P -value
Hematological System Development and Function  
FCER2, IGHE, IGKC, SELE, NT5E, VIPR2. 1.76 × 10-06 - 4.57 × 10-02
Immune Cell Trafficking  
FCER2, IGHE, NT5E, SELE, VIPR2. 1.76 × 10-06 - 4.57 × 10-02
c. R vs. S comparison
DISEASES AND DISORDERS P -value
Gastrointestinal Disease  
CCL26, IL13. 9.85 × 10-06 - 2.62 × 10-02
Hematological Disease  
CCL26, CD1A, IL13, FCER2, IGHE, IGKC, NT5E, SELE, VIPR2. 9.85 × 10-06 - 2.62 × 10-02
PHYSIOLOGICAL SYSTEM DEVELOPMENT AND FUNCTION P-value
Hematological System Development and Function  
CCL26, CD1A, IL13. 2.35 × 10-05 - 4.76 × 10-02
Immune Cell Trafficking  
CCL26, CD1A, IL13. 2.35 × 10-05 - 4.76 × 10-02