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Table 5 Genes most significantly differentially expressed by bMEC stimulated by SaS for 3 and 6 h compared to unstimulated cells, ordered by functional classes

From: Differential response of bovine mammary epithelial cells to Staphylococcus aureus or Escherichia coli agonists of the innate immune system

Gene symbol Gene description Fold change
3 h 6 h
Transcription and activation pathways   
  FOS Proto-oncogene protein c-fos 2.09 2.21
  NFKBIA Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 2.15 2.07
  DUSP1 dual specificity phosphatase 1 1.91 1.71
  ETS2 erythroblastosis virus E26 oncogene homolog 2 (avian)   1.72
  CEBPD CCAAT/enhancer binding protein (C/EBP), delta 1.65 1.59
  SQSTM1 sequestosome 1   1.58
  BIRC3 Baculoviral IAP repeat-containing 3 1.56  
  IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein   1.49
  JUN Jun oncogene 1.57 1.47
  NFKB2 nuclear factor of κ light polypeptide gene enhancer in B-cells 2 -2.05  
  FUS RNA-binding protein FUS   -1.82
  SFRS3 Splicing factor, arginine/serine-rich 3   -1.71
  SFPQ splicing factor proline/glutamine-rich   -1.59
  RABL3 RAB, member of RAS oncogene family-like 3   -1.57
  U2AF1 Splicing factor U2AF   -1.54
  CSTF2 cleavage stimulation factor, 3′pre-RNA, subunit 2   -1.53
  RDBP RNA-binding protein RD, Negative elongation factor E   -1.47
  DKC1 dyskeratosis congenita 1, dyskerin   -1.47
  CRSP9 Cofactor required for Sp1 transcriptional activation subunit 9 -1.45  
Cytokines and chemokines   
  CXCL8 Chemokine (C-X-C motif) ligand 8, Interleukin-8 6.20 4.52
  CCL20 chemokine (C-C motif) ligand 20 4.94 4.27
  CXCL1 Chemokine (C-X-C motif) ligand 1 3.51  
  CXCL3 Chemokine (C-X-C motif) ligand 3 2.48  
  CCL2 chemokine (C-C motif) ligand 2 2.22 2.71
  CXCL5 chemokine (C-X-C motif) ligand 5   2.57
  CXCL2 chemokine (C-X-C motif) ligand 2   2.47
  IL6 Interleukin 6 1.71  
  VEGFB Vascular endothelial growth factor B Precursor   1.47
Immune defense response   
  PLAUR urokinase plasminogen activator surface receptor 1.70 2.46
  LBP lipopolysaccharide binding protein   2.26
  NOS2A Nitric oxide synthase 2A (inducible)   2.05
  CD83 Cell surface protein HB15 1.89 1.73
  CFB complement factor B   1.70
  SQSTM1 sequestosome 1   1.58
  TLR4 toll-like receptor 4   1.50
  ILRAP interleukin 1 receptor accessory protein   1.44
  CD96 Cell surface antigen CD96   1.31
  C3 Complement factor 3   -1.35
  MMP9 Matrix metallopeptidase 9 -1.33  
Stress response   
  SGK1 serum/glucocorticoid regulated kinase 1 1.73 1.75
Cell growth and cycle, apoptosis   
  IER3 immediate early response 3 1.99 1.58
  RASSF1 Ras association domain-containing protein 1   1.52
  CDKN2B cyclin-dependent kinase inhibitor 2B   -1.85
  CDC20 cell division cycle 20 homolog (S. cerevisiae)   -1.60
  CCNA2 cyclin A2   -1.37