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Table 2 EHV-1 induces procoagulant activity primarily in the monocyte-enriched fraction of equine peripheral blood mononuclear cells

From: Equine herpesvirus type 1 infection induces procoagulant activity in equine monocytes

Treatment

Vehicle

RacL11

LPS

Monocyte-enriched*

0

2.36 ± 0.05**

2.78 ± 0.07**

Monocyte-depleted

0

0

0

  1. Monocytes were purified using a murine anti-equine CD14 antibody and procoagulant activity was measured in monocyte-enriched and -depleted PBMC fractions with a two-stage amidolytic assay 4 h after infection with RacL11 (MOI of 5), using LPS (10 ng/mL) positive and vehicle (PBS) negative controls. Data represents the mean ± SD of FXa generation (nM) from 3 horses.
  2. * p < 0.05 comparing all treatments for monocyte-enriched cells.
  3. ** p < 0.05 versus the monocyte-depleted fraction.
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Veterinary Research

ISSN: 1297-9716