Interaction between CTLA-4 signaling in cytotoxic T lymphocytes and Clathrin-mediated endocytosis signaling pathways. A: visual representation of CTLA-4 signaling in cytotoxic T lymphocyte pathway stressing the regulation of molecules taking part in Clathrin-mediated endocytosis signaling. Red and grey nodes are input and IPA-inserted molecules respectively. B: Western blot analysis of CTLA4 and CLTA in MLN at 1, 2 and 6 dpi. C: mRNA quantification of CTLA4 by qPCR. D: expression pattern of CLTA mRNA by microarray analysis.