Figure 2

Some distinctive features of BSE in C57/BL6 mice. (a)-(d) Immunohistochemistry showing characteristic features in CA2 area (a), red nucleus (b), cerebellum (c) and the increased intensity of labelling in locus coeruleus and cochlear nucleus in the medulla (d). (e)–(h) The same areas stained using the PET-blot approach. Both methods revealed similar distribution of PrPSc but IHC confered higher resolution.