Immunization with the immunodominant Helicobacter suis urease subunit B induces partial protection against H. suis infection in a mouse model

Table 2 Gastric inflammation scores in mice after immunization and infection

Group	Inflammation score fundus¹				Inflammation score antrum¹				Overall mean inflammation score/group
Group	0	1	2	3	0	1	2	3	Overall mean inflammation score/group
rUreB	1	6	2	0	7	2	0	0	0.66
rNapA	4	6	0	0	8	2	0	0	0.40
Lysate	1	4	3	0	2	5	1	0	1.06
Sham-immunized	1	5	4	0	5	5	0	0	0.90
Negative control	10	0	0	0	10	0	0	0	0.00

¹Shown are the number of animals per group with a specific overall inflammation score in antrum and/or fundus: animals vaccinated with rUreB (n = 9), rNapA (n = 10) or lysate (n = 8), sham-immunized and infected controls (n = 10) and negative controls (n = 10). 0, no infiltration of mononuclear and/or polymorphonuclear cells; 1, mild diffuse infiltration of mononuclear and/or polymorphonuclear cells; 2, moderate diffuse infiltration of mononuclear and/or polymorphonuclear cells and/or the presence of one or two inflammatory aggregates; 3, marked diffuse infiltration of mononuclear and/or polymorphonuclear cells and/or the presence of at least three inflammatory aggregates.

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