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Figure 1 | Veterinary Research

Figure 1

From: Immunization with the immunodominant Helicobacter suis urease subunit B induces partial protection against H. suis infection in a mouse model

Figure 1

Experimental design of vaccination study. Per group 10 mice were intranasally immunized twice with 3 weeks interval, each time with 30 μg rUreB + 5 μg cholera toxin (CT); 30 μg rNapA + 5 μg CT, and 100 μg HS5 lysate + 5 μg CT (groups 1, 2 and 3, respectively). Groups 4 (sham-immunized group) and 5 (negative control group) were intranasally inoculated with HBSS. Three weeks after the second immunization, blood was collected from 5 mice per group and one week later mice of groups 1, 2, 3 and 4 were intragastrically inoculated with 108 viable H. suis bacteria. Group 5 was intragastrically inoculated with HBSS. Four weeks after intragastric challenge, mice were euthanized.

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Veterinary Research

ISSN: 1297-9716