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Table 2 Vaccine trials using a variety of antigen-preparation methods during the last decade

From: Pathogenesis of and strategies for preventing Edwardsiella tarda infection in fish

No. Antigen Adjuvant fish Route RPS (%)* Country year Ref.
1 recombinant vaccine DnaJ aluminum hydroxide olive flounder i.p. 62 China 2011 [106]
2 recombinant vaccine OMP - common carp i.p. 54.3 India 2011 [107]
3 natural OMVs - olive flounder i.p. 70 Korea 2011 [93]
4 Δalr Δasd E. tarda - olive flounder i.p. 100 Korea 2011 [108]
5 recombinant vaccine rEta2 aluminum hydroxide olive flounder i.p. 83 China 2011 [109]
6 DNA vaccine pCEta2 - olive flounder i.m. 67 China 2011 [109]
7 recombinant vaccine pCEsa1 - olive flounder i.p. 57 China 2011 [110]
8 Esa1-expressing recombinant strain aluminum hydroxide olive flounder PO 52 China 2010 [111]
9 Esa1-expressing recombinant strain aluminum hydroxide olive flounder i.p. 79 China 2010 [111]
10 Live E22 - olive flounder i.p. 45 Japan 2010 [112]
11 DNA vaccine N163 - olive flounder i.m. 70.2 China 2010 [113]
12 recombinant vaccine scFv Freund's incomplete adjuvant Red drum i.p. 88 China 2010 [114]
13 recombinant vaccine EseD Freund’s complete adjuvant turbot i.p. 62.5 China 2010 [62]
14 recombinant vaccine DegPEt Freund's incomplete adjuvant olive flounder i.p. 89 China 2010 [81]
15 Recombinant vaccine Et49 Freund's incomplete adjuvant olive flounder i.p. 47 China 2010 [81]
16 Live ATCC 15947 - olive flounder i.p. 100 China 2010 [115]
17 Extracted OMP Freund's incomplete adjuvant olive flounder i.p. 71 China 2010 [97]
18 recombinant vaccine Eta21 Bacillus sp. strain B187 olive flounder i.p. 69 China 2009 [116]
19 DH5α/pTAET21 Bacillus sp. strain B187 olive flounder i.p. 100 China 2009 [116]
20 DNA vaccine pEta6 - olive flounder i.m. 50 China 2009 [117]
21 recombinant vaccine Eta6 Bacillus sp. strain B187 olive flounder i.p. 53 China 2009 [117]
22 recombinant vaccine Et18 Bacillus sp. strain B187 olive flounder i.p. 61 China 2009 [118]
23 recombinant vaccine EseD Bacillus sp. strain B187 olive flounder i.p. 51.3 China 2009 [118]
24 Formalin killed ACC35.1 Montanide ISA 763 AVG turbot i.p. 100 Spain 2008 [55]
25 live, attenuated esrB mutant - turbot i.p. 93.3 China 2007 [119]
26 Ghost vaccine - olive flounder PO 85.7 Korea 2007 [120]
27 Ghost vaccine - tilapia i.p. 88.8 Korea 2006 [121]
28 37 kDa OMP - olive flounder i.p. 70 Japan 2004 [122]
29 Formalin killed virulent bacterin - Indian major carp immersion 98 India 2002 [37]
  1. “-” means no adjuvant was added; i.p., intraperitoneal injection; i.m., intramuscular injection; PO, oral administration; *, relative percentage survival (RPS) calculating for vaccine efficacy (RPS = [1 minus vaccine group mortality/control group mortality] x 100).