Figure 3From: Salmonella Typhimurium induces SPI-1 and SPI-2 regulated and strain dependent downregulation of MHC II expression on porcine alveolar macrophagesCorrelation between MHC II downregulation and invasion capacity, cytotoxicity or ROS production. Correlation between Salmonella induced MHC II downregulation (X-axis) and (A) Salmonella invasion capacity, (B) macrophage viability or (C) ROS production (on the respective Y-axes) with r = Pearson correlation coefficient. MHC II downregulation capacity is presented as the average mean FL-5 signal ratios between infected and uninfected porcine alveolar macrophages (PAMinf and PAMuninf, respectively). Salmonella invasion capacity is expressed as the number of macrophages infected by a particular Salmonella strain relative to the macrophages infected by strain 112910a. Viability is expressed as the average percentage of viable cells at 24 h post inoculation relative to viable uninfected macrophages (negative control). ROS production of infected macrophages was expressed relative to the ROS production of phorbol 12-myristate 13-acetate (PMA) treated macrophages (positive control). ROS = reactive oxygen species; PAM = porcine alveolar macrophagesBack to article page