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Table 1 Stability analysis of the E2 TAV escape variants D9, B5/2, Q7, S10, and O11 using partial sequencing of viral proteins E1, E2, and E RNS (numbers indicate nucleotide positions differing from the parental C-strain “Riems”)

From: Characterization of C-strain “Riems” TAV-epitope escape variants obtained through selective antibody pressure in cell culture

Escape variant D9 3rd passage B5/2 6thpassage S10-4thpassage 011-5thpassage Q7-6thpassage Q7-14thpassage S10-18thpassage O11-17thpassage Resulting amino acid exchange C-strain to escape variant
Viral protein          
E RNS 1649 1649 1649 1649 1649 1649 1649 1649 Isoleucin to Valine
E1 - - 2099 2099 2099 2099 2099 2099 Tyrosine to Histidine
   2122 2122 2122 2122 2122 2122 2122 Aspartic acid to Glutamic acid
E2 - - 2862 2862 2862 2862 2862 2862 Alanine to Valine
  2870 2870 2870 2870 2870 2870 2870 2870 Proline to Serine
  - 2889 2889 2889 2889 2889 2889 2889 Glutamic acid to Glycine