Histopathological analysis of footpad skin from mice subcutaneously infected with 104 amastigotes of L. amazonensis. A and B: C3H.He mice 90 days after infection. A: Proliferation and arrangement of collagen fibre (plain arrow) compatible to dermis restoration (Masson); B: Dermo-epidermic junction shows preserved elastic (thin arrow) and elaunin fibres (thick arrow) (Weigert); C: BALB/c mice 120 days after infection. Diffuse inflammatory infiltrate (***) composed of PMN and macrophages heavily parasitized (arrowhead); D: C3H.He mice 120 dpi. (HE). It was observed an absence of lesions and regeneration of tissue architecture.