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Table 5 The 20 most down-regulated transcripts detected in Expts 1 and 2 (FDR ≤ 0.05)

From: Novel gene expression responses in the ovine abomasal mucosa to infection with the gastric nematode Teladorsagia circumcincta

Sequence.ID TIGR_TC TC.description Gene symbol Fold Change
EXPT 1 Comparison = d5Nv_d0Nv
KN511_9487m11.p1kM13F TC336019 UP|MMP13_BOVIN (O77656) Collagenase 3 precursor (Matrix metalloproteinase-13) (MMP-13), complete MMP13 -2.68
KN511_9481c03.p1kaM13F TC304583 UP|LYSC1_BOVIN (Q06285) Lysozyme C-1 precursor (1,4-beta-N-acetylmuramidase C), complete LYZ2 -2.37
KN511_9476d13.p1kaM13F TC304583 UP|LYSC1_BOVIN (Q06285) Lysozyme C-1 precursor (1,4-beta-N-acetylmuramidase C), complete LYZ2 -2.33
KN511_9485a08.p1kM13F TC302650 milk lysozyme [Bos taurus] LYZ1 -2.30
KN511_9485g08.p1kM13F TC346615 similar to UP|O97916_BOVIN (O97916) Reverse transcriptase-like, partial (32%) --- -2.23
KN511_9257d12.p1kaM13F TC322737 similar to UP|Q3VD89_9SPHN (Q3VD89) ABC-2, partial (5%) --- -2.16
KN511_9257a18.p1kaM13F TC308928 similar to GB|AAK18773.1|13324523|F272846S31 Fanconi anemia complementation group D2 protein, isoform 2 {Homo sapiens} (exp = -1; wgp = 0; cg = 0), partial (18%) LOC515845 -2.14
KN511_9262d01.p1kaM13F --- --- --- -2.12
KN511_9261n23.p1kaM13F TC362037 homologue to UP|IFRD1_PIG (Q5S1U6) Interferon-related developmental regulator 1, complete IFRD1 -2.12
KN511_9476d14.p1kaM13F TC349311 similar to UP|NEK4_HUMAN (P51957) Serine/threonine-protein kinase Nek4 (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2), partial (33%) MGC159441 -2.08
KN511_9261o08.p1kaM13F TC305060 homologue to UP|Q96BA7_HUMAN (Q96BA7) HNRPU protein, partial (93%) MGC142835 -2.07
KN511_9258d23.p1kaM13F --- --- --- -2.07
KN511_9487p21.q1kM13R TC342358 homologue to UP|DC1L2_HUMAN (O43237) Cytoplasmic dynein 1 light intermediate chain 2 (Dynein light intermediate chain 2, cytosolic) (LIC53/55) (LIC-2), complete LOC519789 -2.05
KN511_9262k18.p1kaM13F TC375209 similar to UP|ZSWM3_HUMAN (Q96MP5) Zinc finger SWIM domain-containing protein 3, partial (27%) LOC512244 -2.05
KN511_9485d23.q1kM13R TC365645 UP|LYSC2_BOVIN (Q06283) Lysozyme C-2 precursor (1,4-beta-N-acetylmuramidase C), complete LYZ2 -2.04
KN511_9254g13.p1kaM13F TC319944 --- --- -2.02
KN511_9487h17.p1kM13F TC327406 UP|Q5DTN6_MOUSE (Q5DTN6) MKIAA4095 protein (Fragment), partial (8%) LOC614823 -1.96
CO202908 TC360504 UP|Q3MHM4_BOVIN (Q3MHM4) Heat shock 70 kDa protein 8, complete HSPA8 -1.87
KN511_9482g13.p1kM13F TC331274 homologue to UP|TENA_PIG (Q29116) Tenascin precursor (TN) (Hexabrachion) (Cytotactin) (Neuronectin) (GMEM) (JI) (Miotendinous antigen) (Glioma-associated-extracellular matrix antigen) (GP 150-225) (Tenascin-C) (TN-C) (P230), partial (10%) MGC140517 -1.87
KN511_9482f05.p1kM13F TC377013 --- --- -1.86
EXPT 1 Comparison = d5Im_d5Nv   
KN511_9256g17.p1kaM13F TC314535 homologue to UP|Q94513_DROME (Q94513) Boundary element associated factor (LD44361p) (CG10159-PB, isoform B), partial (5%) --- -6.51
KN511_9256g17.p1kaM13F TC314535 homologue to UP|Q94513_DROME (Q94513) Boundary element associated factor (LD44361p) (CG10159-PB, isoform B), partial (5%) --- -5.97
KN511_9254l23.p1kaM13F TC354719 similar to UP|TFF2_HUMAN (Q03403) Trefoil factor 2 precursor (Spasmolytic polypeptide) (SP) (Spasmolysin), complete MGC139191 -5.54
KN511_9257l15.p1kaM13F TC354719 similar to UP|TFF2_HUMAN (Q03403) Trefoil factor 2 precursor (Spasmolytic polypeptide) (SP) (Spasmolysin), complete MGC139191 -5.42
KN511_9260b10.p1kaM13F TC365645 UP|LYSC2_BOVIN (Q06283) Lysozyme C-2 precursor (1,4-beta-N-acetylmuramidase C), complete LYZ2 -3.92
KN511_9260m19.p1kaM13F TC304583 UP|LYSC1_BOVIN (Q06285) Lysozyme C-1 precursor (1,4-beta-N-acetylmuramidase C), complete LYZ2 -3.79
KN511_9483j03.p1kM13F TC365645 UP|LYSC2_BOVIN (Q06283) Lysozyme C-2 precursor (1,4-beta-N-acetylmuramidase C), complete LYZ2 -3.52
KN511_9265j02.p1kaM13F CB220717 --- --- -3.45
KN511_9264e04.p1kaM13F TC314849 UP|Q6SJV6_BOVIN (Q6SJV6) Foveolin precursor, complete FOV -3.33
KN511_9262k17.p1kaM13F TC304583 UP|LYSC1_BOVIN (Q06285) Lysozyme C-1 precursor (1,4-beta-N-acetylmuramidase C), complete LYZ2 -3.25
KN511_9476c18.p1kaM13F TC365645 UP|LYSC2_BOVIN (Q06283) Lysozyme C-2 precursor (1,4-beta-N-acetylmuramidase C), complete LYZ2 -3.25
KN511_9476d13.p1kaM13F TC304583 UP|LYSC1_BOVIN (Q06285) Lysozyme C-1 precursor (1,4-beta-N-acetylmuramidase C), complete LYZ2 -3.17
KN511_9488a15.p1kM13F TC365645 UP|LYSC2_BOVIN (Q06283) Lysozyme C-2 precursor (1,4-beta-N-acetylmuramidase C), complete LYZ2 -3.16
KN511_9259k01.p1kaM13F TC365645 UP|LYSC2_BOVIN (Q06283) Lysozyme C-2 precursor (1,4-beta-N-acetylmuramidase C), complete LYZ2 -3.14
KN511_9265m20.p1kaM13F TC304583 UP|LYSC1_BOVIN (Q06285) Lysozyme C-1 precursor (1,4-beta-N-acetylmuramidase C), complete LYZ2 -3.10
KN511_9263j17.p1kaM13F TC323852 similar to UP|Q86XP6_HUMAN (Q86XP6) GDDR (Blottin precursor) (TFIZ1 protein precursor), complete LOC512001 -3.10
KN511_9487e19.p1kM13F TC365645 UP|LYSC2_BOVIN (Q06283) Lysozyme C-2 precursor (1,4-beta-N-acetylmuramidase C), complete LYZ2 -3.08
KN511_9485d23.q1kM13R TC365645 UP|LYSC2_BOVIN (Q06283) Lysozyme C-2 precursor (1,4-beta-N-acetylmuramidase C), complete LYZ2 -3.05
KN511_9486h17.p1kM13F TC314849 UP|Q6SJV6_BOVIN (Q6SJV6) Foveolin precursor, complete FOV -3.04
KN511_9265h22.p1kaM13F TC304583 UP|LYSC1_BOVIN (Q06285) Lysozyme C-1 precursor (1,4-beta-N-acetylmuramidase C), complete LYZ2 -2.99
EXPT 2 Comparison = Day 0 Im vs Day 0 Nv   
KN511_9484p13.p1kM13F TC376600 similar to UP|CENPA_MOUSE (O35216) Centromere protein A (CENP-A) (Centromere autoantigen A), partial (15%) CENP-A -1.75
KN511_9479i16.p1kaM13F --- --- --- -1.75
KN511_9253l11.p1kaM13F TC303509 homologue to UP|RIR2_HUMAN (P31350) Ribonucleoside-diphosphate reductase M2 subunit (Ribonucleotide reductase small subunit) (Ribonucleotide reductase small chain), partial (88%) RRM2 -1.73
KN511_9488d17.p1kM13F TC314207 similar to UP|TOP2A_PIG (O46374) DNA topoisomerase 2-alpha (DNA topoisomerase II, alpha isozyme), partial (17%) TOP2A -1.71
KN511_9265l09.p1kaM13F TC340393 UP|CCNA2_BOVIN (P30274) Cyclin-A2 (Cyclin-A) (Fragment), complete CCNA2 -1.70
KN511_9488f20.p1kM13F TC355225 homologue to UP|BIRC5_CANFA (Q8I009) Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor survivin), complete BIRC5 -1.66
KN511_9487m04.p1kM13F TC355225 homologue to UP|BIRC5_CANFA (Q8I009) Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor survivin), complete BIRC5 -1.65
KN511_9253i15.p1kaM13F TC340307 UP|CP51A_BOVIN (Q4PJW3) Cytochrome P450 51A1 (CYPLI) (P450LI) (Sterol 14-alpha demethylase) (Lanosterol 14-alpha demethylase) (LDM) (P450-14DM) (P45014DM), complete CYP51 -1.63
KN511_9265a16.p1kaM13F TC303827 --- KIF11 -1.58
KN511_9264b09.p1kaM13F --- --- --- -1.56
KN511_9256j19.p1kaM13F TC355225 homologue to UP|BIRC5_CANFA (Q8I009) Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor survivin), complete BIRC5 -1.53
KN511_9261d22.p1kaM13F --- --- --- -1.50
KN511_9481l06.p1kaM13F TC303509 homologue to UP|RIR2_HUMAN (P31350) Ribonucleoside-diphosphate reductase M2 subunit (Ribonucleotide reductase small subunit) (Ribonucleotide reductase small chain), partial (88%) LOC508167 -1.49
KN511_9476j14.p1kaM13F TC333525 homologue to GB|AAH08056.2|39644830|BC008056 PLEK2 protein {Homo sapiens} (exp = -1; wgp = 0; cg = 0), partial (21%) MGC142714 -1.48
KN511_9482e10.p1kM13F TC330132 similar to UP|CV106_HUMAN (Q6P0N0) Protein C14orf106 (P243), partial (33%) LOC507661 -1.47
KN511_9257p16.p1kaM13F TC340307 UP|CP51A_BOVIN (Q4PJW3) Cytochrome P450 51A1 (CYPLI) (P450LI) (Sterol 14-alpha demethylase) (Lanosterol 14-alpha demethylase) (LDM) (P450-14DM) (P45014DM), complete CYP51 -1.46
KN511_9256f06.p1kaM13F TC332145 similar to UP|Q9BDH4_PIG (Q9BDH4) Amphiregulin long form, complete MGC152310 -1.45
CN824006 TC306385 homologue to UP|Q4S6A0_TETNG (Q4S6A0) Chromosome 9 SCAF14729, whole genome shotgun sequence, partial (59%) LOC404053 -1.42
KN511_9257i02.p1kaM13F TC327524 homologue to UP|Q9BW51_HUMAN (Q9BW51) TTK protein kinase, partial (44%) LOC524925 -1.41
KN511_9261e22.p1kaM13F TC301804 homologue to UP|IMA2_HUMAN (P52292) Importin alpha-2 subunit (Karyopherin alpha-2 subunit) (SRP1-alpha) (RAG cohort protein 1), complete KPNA2 -1.41
EXPT 2 Comparison = Day 2 Im vs Day 0 Im   
KN511_9479k18.p1kaM13F CX950602 --- --- -3.53
KN511_9488b02.p1kM13F DY126632 --- --- -3.24
KN511_9257l15.p1kaM13F TC354719 similar to UP|TFF2_HUMAN (Q03403) Trefoil factor 2 precursor (Spasmolytic polypeptide) (SP) (Spasmolysin), complete TFF2 -3.14
KN511_9254l23.p1kaM13F TC354719 similar to UP|TFF2_HUMAN (Q03403) Trefoil factor 2 precursor (Spasmolytic polypeptide) (SP) (Spasmolysin), complete TFF2 -3.03
KN511_9264e04.p1kaM13F TC314849 UP|Q6SJV6_BOVIN (Q6SJV6) Foveolin precursor, complete FOV -2.81
KN511_9263j17.p1kaM13F TC323852 similar to UP|Q86XP6_HUMAN (Q86XP6) GDDR (Blottin precursor) (TFIZ1 protein precursor), complete GKN2 -2.45
KN511_9486h17.p1kM13F TC314849 UP|Q6SJV6_BOVIN (Q6SJV6) Foveolin precursor, complete FOV -2.09
KN511_9261k22.p1kaM13F TC327109 similar to UP|O97916_BOVIN (O97916) Reverse transcriptase-like, partial (21%) --- -1.93
KN511_9486b13.p1kM13F TC341767 --- --- -1.90
KN511_9484h13.p1kM13F TC350450 similar to UP|UDB5_MOUSE (P17717) UDP-glucuronosyltransferase 2B5 precursor (UDPGT) (M-1), partial (49%) UGT2B17 -1.81
KN511_9263c22.p1kaM13F --- --- --- -1.80
KN511_9264a19.p1kaM13F --- --- --- -1.77
KN511_9484l14.p1kM13F TC362885 similar to UP|MALAT_HUMAN (Q9UHZ2) Metastasis-associated lung adenocarcinoma transcript 1, partial (72%) MALAT1 -1.75
KN511_9480l06.p1kaM13F TC362885 similar to UP|MALAT_HUMAN (Q9UHZ2) Metastasis-associated lung adenocarcinoma transcript 1, partial (72%) MALAT1 -1.74
KN511_9481o23.p1kaM13F TC350450 similar to UP|UDB5_MOUSE (P17717) UDP-glucuronosyltransferase 2B5 precursor (UDPGT) (M-1), partial (49%) UGT2B17 -1.73
CN824758 --- --- --- -1.72
KN511_9488a17.p1kM13F TC318925 --- --- -1.71
KN511_9480o03.p1kaM13F --- --- --- -1.70
KN511_9263o20.p1kaM13F TC380127 similar to UP|UDB5_MOUSE (P17717) UDP-glucuronosyltransferase 2B5 precursor (UDPGT) (M-1), partial (42%) UGT2B17 -1.70
KN511_9484i14.p1kM13F TC362885 similar to UP|MALAT_HUMAN (Q9UHZ2) Metastasis-associated lung adenocarcinoma transcript 1, partial (72%) MALAT1 -1.67
  1. The experiment and the samples being compared are given as subheadings at the top of each section. Nv = "naïve" yearlings, worm naïve prior to challenge; Im = "immune" yearlings, previously infected by trickle infection prior to challenge, d = days post-challenge. Details of the experimental trials and hybridisation design are given in Tables 1 and 2.
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Veterinary Research

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