Table 1 Average distribution of nucleoprotein antigen, as determined by immunohistochemistry, in tissues sampled from red-legged partridges (Alectoris rufa) intranasally inoculated with A/Chicken/Italy/5093/1999 (H7N1) influenza virus
Tissue | 3 dpi | 6 dpi | 8 dpi | Predominant cell types |
|---|---|---|---|---|
Esophagus | - | - | - | - |
Crop | - | + | - | Squamous polistratified epithelial cells |
Proventriculus | - | + | - | Epithelial cells of the gastric glands |
Gizzard | + | ++ | + | Epithelial cells of the gastric glands, cells of the muscularis externa |
Duodenum | - | - | - | - |
Jejunum-Ileum | - | - | - | - |
Cecum/Cecal tonsil | - | + | - | Epithelial cells of the glands, cells of the muscularis externa |
Colon | - | - | - | - |
Rectum | - | - | - | - |
Pancreas | + | + | + | Acinar cells, endothelial cells |
Liver | + | + | + | Kupffer cells, endothelial cells |
Kidney | ++ | +++ | ++ | Tubular epithelial cells, endothelial cells |
Adrenal gland | + | +++ | +++ | Corticotrophic, corticotropic cells |
Gonad | - | - | + | Epithelial cells of the oviduct |
Nasal turbinates | - | + | + | Olfactory epithelial cells, respiratory epithelial cells, epithelial cells of the infraorbital sinuses, salivary and nasal glands |
Trachea | + | - | + | Pseudostratified epithelial cells |
Lung | + | + | + | Air capillaries cells, macrophages, endothelial cells |
Heart | - | + | + | Myocardyocytes, endothelial cells |
Breast muscle | - | + | - | Myocytes, endothelial cells |
Skin | - | ++ | + | Epithelial cells of epidermal collar of feather follicles, endothelial cells of pulp |
Bone marrow | - | - | - | - |
Spleen | + | + | + | Macrophages, endothelial cells |
Bursa of Fabricius | - | + | - | Macrophages, endothelial cells |
Thymus | - | - | - | - |
Brain | - | ++ | +++ | Neurons, ependymal cells, glial cells |
Spinal cord | - | + | ++ | Neurons, ependymal cells, cells of the leptomeninges |
Sciatic nerve | - | - | - | - |