Table 2 Significant regression values between gene or protein expression and scrapie-related lesions, as obtained by stepwise regression analysis
From: Changes in HSP gene and protein expression in natural scrapie with brain damage
Prion | Spongiosis | Vacuolation | GFAP | LGS | Caspase3 | |
|---|---|---|---|---|---|---|
Medulla oblongata | ||||||
HSP27 | 0.399 (0.003)1 | -0.381 (0.016) | ns2 | -0.443 (0.043) | ns | ns |
HSP72 | ns | ns | ns | ns | ns | ns |
HSP73 | ns | ns | ns | ns | ns | ns |
HSP90 | ns | ns | ns | ns | ns | ns |
Hsp70p | ns | ns | ns | ns | ns | |
Hsp90p | ns | ns | ns | ns | ns | ns |
Cerebellum | ||||||
HSP27 | -0.178 (0.032) | ns | ns | 0.294 (0.0430) | ns | ns |
HSP72 | ns | ns | ns | ns | ns | ns |
HSP73 | -0.719 (0.015) | 0.317 (0.023) | ns | 0.783 (0.034) | 0.555 (0.018) | ns |
HSP90 | -0.465 (0.008) | 0.182 (0.039) | ns | 0.712 (0.01) | ns | ns |
Hsp70p | ns | -0.014 (0.010) | ns | ns | 0.022 (0.02) | 0.026 (0.010) |
Hsp90p | ns | ns | ns | ns | ns | ns |
Prefrontal cortex | ||||||
HSP27 | -0.228 (0.004) | ns | ns | 0.267 (0.025) | -0.129 (0.038) | ns |
HSP72 | -0.347 (0.003) | ns | ns | 0.277 (0.034) | ns | ns |
HSP73 | -0.271 (0.036) | ns | ns | 0.381 (0.03) | ns | ns |
HSP90 | ns | ns | ns | ns | ns | ns |
Hsp70p | ns | ns | -0.049 (0.015) | 0.045 (0.013) | -0.023 (0.018) | ns |
Hsp90p | ns | ns | -0.080 (0.002) | 0.046 (0.015) | -0.024 (0.020) | ns |
Diencephalon | ||||||
HSP27 | ns | ns | ns | ns | ns | ns |
HSP72 | ns | ns | ns | ns | ns | ns |
HSP73 | ns | ns | ns | ns | ns | ns |
HSP90 | ns | ns | ns | ns | ns | ns |
Hsp70p | ns | -0.805 (0.001) | ns | 0.778 (0.002) | ns | ns |
Hsp90p | ns | ns | ns | ns | ns | ns |