Identification of a novel risk factor for chronic wasting disease (CWD) in elk: S100G single nucleotide polymorphism (SNP) of the prion protein gene (PRNP)

Lee, Yu-Ran; Kim, Yong-Chan; Won, Sae-Young; Jeong, Min-Ju; Park, Kyung-Je; Park, Hoo-Chang; Roh, In-Soon; Kang, Hae-Eun; Sohn, Hyun-Joo; Jeong, Byung-Hoon

doi:10.1186/s13567-023-01177-7

Veterinary Research

Table 1 Comparison of genotype and allele distributions of the prion protein gene (PRNP) between chronic wasting disease (CWD)-negative and CWD-positive elks

From: Identification of a novel risk factor for chronic wasting disease (CWD) in elk: S100G single nucleotide polymorphism (SNP) of the prion protein gene (PRNP)

Polymorphisms			Genotype frequencies, n			Allele frequencies, n		HWE	P-value^a	P-value^b
Polymorphisms			MM	Mm	mm	M	m	HWE	P-value^a	P-value^b
c.56G > A	S19N	CWD-neg	188	8	0	384	8	0.7705	1	1
		CWD-pos	50	2	0	102	2	0.8875
c.63C > T, G	V21V	CWD-neg	88	84	24	260	132	0.5701	0.0322	0.0024
		CWD-pos	34	17	1	85	19	0.4945
c.93A > C	G31G	CWD-neg	192	3	1	387	5	0	1	0.589
		CWD-pos	52	0	0	104	0	N.A
c.95G > A	G32E	CWD-neg	195	1	0	391	1	0.9714	1	1
		CWD-pos	52	0	0	104	0	N.A
c.135A > C	G45G	CWD-neg	191	4	1	386	6	0	0.6696	0.3516
		CWD-pos	52	0	0	104	0	N.A
c.292A > G	T98A	CWD-neg	177	19	0	373	19	0.4757	0.0851	0.0918
		CWD-pos	51	1	0	103	1	0.9441
c.293C > G	T98S	CWD-neg	192	3	1	387	5	0	1	0.589
		CWD-pos	52	0	0	104	0	N.A
c.298A > G	S100G	CWD-neg	196	0	0	392	0	N.A	< 0.0001	< 0.0001
		CWD-pos	46	6	0	98	6	0.6588
c.310A > G	K104E	CWD-neg	195	0	1	390	2	0	1	1
		CWD-pos	52	0	0	104	0	N.A
c.312G > A	K104K	CWD-neg	139	53	4	331	61	0.685	0.0748	0.0199
		CWD-pos	45	7	0	97	7	0.6027
c.384C > T	L128L	CWD-neg	183	12	1	378	14	0.1198	0.1585	0.0491
		CWD-pos	52	0	0	104	0	N.A
c.394A > T	M132L	CWD-neg	135	50	11	320	72	0.0365	0.8542	0.479
		CWD-pos	38	12	2	88	16	0.4125
c.408C > T	A136A	CWD-neg	173	22	1	368	24	0.7416	0.0058	0.0052
		CWD-pos	37	15	0	89	15	0.2242
c.414C > T	S138S	CWD-neg	188	7	1	383	9	0.0043	0.4868	0.215
		CWD-pos	52	0	0	104	0	N.A
c.424A > G	I142V	CWD-neg	195	1	0	391	1	0.9714	1	1
		CWD-pos	52	0	0	104	0	N.A
c.428A > G	H143R	CWD-neg	193	3	0	389	3	0.914	1	1
		CWD-pos	51	1	0	103	1	0.9441
c.436A > T	N146Y	CWD-neg	195	1	0	391	1	0.9714	1	1
		CWD-pos	52	0	0	104	0	N.A
c.441C > T	D147D	CWD-neg	195	0	1	390	2	0	1	1
		CWD-pos	52	0	0	104	0	N.A
c.478 T > C	Y160H	CWD-neg	195	1	0	391	1	0.9714	1	1
		CWD-pos	52	0	0	104	0	N.A
c.501G > A	R167R	CWD-neg	183	12	1	378	14	0.1198	0.1585	0.0491
		CWD-pos	52	0	0	104	0	N.A
c.518A > G	N173S	CWD-neg	192	3	1	387	5	0	1	0.589
		CWD-pos	52	0	0	104	0	N.A
c.530C > A	T177N	CWD-neg	186	9	1	381	11	0.2677	0.3762	0.1312
		CWD-pos	52	0	0	104	0	N.A
c.550A > G	N184D	CWD-neg	195	1	0	391	1	0.9714	1	1
		CWD-pos	52	0	0	104	0	N.A
c.624G > A	M208I	CWD-neg	190	4	2	384	8	0	0.7389	0.2139
		CWD-pos	52	0	0	104	0	N.A
c.636 T > G	V212V	CWD-neg	187	7	2	381	11	0	0.4741	0.1312
		CWD-pos	52	0	0	104	0	N.A
c.676C > G	Q226E	CWD-neg	165	28	3	358	34	0.1689	0.5108	0.7639
		CWD-pos	42	10	0	94	10	0.4429

Bold texts indicate P < 0.05.
^acompared genotype distributions between CWD-negative and CWD-positive elks.
^bcompared allele distributions between CWD-negative and CWD-positive elks.
CWD-neg: CWD-negative elks, CWD-pos: CWD-positive elks, HWE: Hardy–Weinberg equilibrium, M: major allele, m: minor allele, MM: major homozygote, Mm: heterozygote, mm: minor homozygote, N.A: not applicable.

Back to article page

ISSN: 1297-9716

Contact us

Submission enquiries: veterinary.research@inrae.fr
General enquiries: info@biomedcentral.com