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Figure 7 | Veterinary Research

Figure 7

From: Host E3 ligase Hrd1 ubiquitinates and degrades H protein of canine distemper virus to inhibit viral replication

Figure 7

Proposed model for how Hrd1 influences CDV H protein to inhibit viral replication in cells. The model shows that the E3 ubiquitin ligase Hrd1 located in ER interacts with CDV H protein, and Hrd1 transfers the activated K63-linked ubiquitin molecules to lysine residues in the 115 site (K115) of substrate protein CDV H. Then, the ubiquitinated CDV H protein is transported to cytoplasm and degraded via the 26 s proteasome. Finally, the degradation of CDV H reduces viral growth.

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