Figure 7From: Host E3 ligase Hrd1 ubiquitinates and degrades H protein of canine distemper virus to inhibit viral replicationProposed model for how Hrd1 influences CDV H protein to inhibit viral replication in cells. The model shows that the E3 ubiquitin ligase Hrd1 located in ER interacts with CDV H protein, and Hrd1 transfers the activated K63-linked ubiquitin molecules to lysine residues in the 115 site (K115) of substrate protein CDV H. Then, the ubiquitinated CDV H protein is transported to cytoplasm and degraded via the 26Â s proteasome. Finally, the degradation of CDV H reduces viral growth.Back to article page