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Figure 11 | Veterinary Research

Figure 11

From: The novel Nsp9-interacting host factor H2BE promotes PEDV replication by inhibiting endoplasmic reticulum stress-mediated apoptosis

Figure 11

PEDV upregulates H2BE expression to inhibit ER stress-mediated apoptosis. PEDV Nsp9 upregulates H2BE expression by regulating IRX1 expression. Overexpression of H2BE inhibits PEDV-induced activation of the ER stress-driven PERK and IRE1 pathways and suppresses CHOP expression and apoptosis. Inhibition of apoptosis promotes PEDV replication.

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