Figure 8
From: Porcine epidemic diarrhea virus activates PERK-ROS axis to benefit its replication in Vero E6 cells
Schematic illustration of PEDV-induced activation of the PERK-CHOP-ERO1α axis and increased generation of ROS to promote viral replication in Vero E6 cells. PEDV infection induces ER stress by activating the PERK-eIF2α pathway which in turn activates CHOP. CHOP transcriptionally upregulates ERO1α which initiates oxidative stress by generating ROS during protein folding. Inhibition of PERK by shRNA or GSK2606414, CHOP knockdown by siRNA or ERO1α inhibition by shRNA or EN460 all lead to alleviation of ROS generation and reduced viral replication in PEDV-infected Vero E6 cells.