Table 2 Significant increases and decreases of cytokine expression between groups at different time-points.
Early stages | Late stage | ||||
|---|---|---|---|---|---|
4 dpi | 8 dpi | 16 dpi | 100 dpi | ||
Liver | PI vs UC | ⇊ IFN-γ ↑ IL-4 ↓ FoxP3 | ⇈ TNF-α; IL-10; TGF-β; IL-4; FoxP3 | ⇈ IL-1β; TNF-α; IL-10; TGF-β; IL-4; FoxP3 | ⇈ IL-1β; TNF-α; IL-4 |
RI vs UC | ⇈ IL-1β; IFN-γ; TNF-α; IL-10; TGF-β; IL-4; FoxP3 | ⇈ IL-1β; IFN-γ; TNF-α; IL-10; TGF-β; IL-4; FoxP3 | ⇈ IL-1β; IFN-γ; TNF-α; IL-10; TGF-β; IL-4; FoxP3 | ⇈ IL-10; TGF-β; IL-4; FoxP3 ↑ IL-1β | |
RI vs PI | ⇈ IL-1β; IFN-γ; TNF-α; IL-10; TGF-β; IL-4; FoxP3 | ⇈ IL-1β; IFN-γ; TGF-β ↑ FoxP3 | ⇈ IFN-γ; IL-4 ↑ TGF-β ⇊ IL-1β | ⇈ IL-10; TGF-β | |
HLN | PI vs UC | ⇈ IL-1β; TNF-α; FoxP3 ↑IL-4 ⇊ IFN-γ | ⇈ IL-1β; TNF-α; IL-4; FoxP3 ↑ TGF-β ⇊ IL-10 ↓ IFN-γ | ⇈ IL-1β; IL-4; FoxP3 ⇊ IFN-γ; IL-10; TGF-β | ⇈ IL-4 ⇊ IFN-γ; TNF-α; IL-10; TGF-β; FoxP3 |
RI vs UC | ⇈ IL-4 ⇊ IFN-γ; TNF-α IL-10; TGF-β ↓ FoxP3 | ⇈ IL-4 ⇊ IFN-γ; IL-10; TGF-β | ⇈ IL-1β; IL-4 ⇊ IFN-γ; TNF-α; IL-10; TGF-β; FoxP3 | ⇈ IL-1β; TNF-α; TGF-β; FoxP3 ⇊ IFN-γ | |
RI vs PI | ⇈ IL-4 ⇊ IFN-γ; TNF-α IL-10; TGF-β; FoxP3; ⇂ IL-1β | ⇊ IL -1β; IFN-γ; TNF-α; IL-10; TGF-β; FoxP3 | ⇊ IFN-γ; TNF-α; TGF-β; FoxP3 ↑ IL-4 | ⇈ IL-1β; IFN-γ; TNF-α; IL-10; TGF-β; FoxP3 ⇊ IL-4 | |