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Figure 13 | Veterinary Research

Figure 13

From: Chicken telomerase reverse transcriptase promotes the tumorigenicity of avian leukosis virus subgroup J by regulating the Wnt/β-catenin signaling pathway

Figure 13

Schematic diagram of the molecular mechanism by which chTERT promotes ALV-J to induce tumor formation. In this study, continuous overexpression of chTERT gene in chickens can promote the tumorigenicity of chronic translational ALV-J by enhancing the Wnt/β-catenin signaling pathway and further increased the expression level of c-Myc, inhibited tumor cell apoptosis, and promoted the replication of ALV-J.

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Veterinary Research

ISSN: 1297-9716