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Table 2 Phosphorylation substrates of UL13 homologous protein kinases in alphaherpesvirus

From: Regulation of alphaherpesvirus protein via post-translational phosphorylation

Alphaherpesvirus

Phosphorylated protein

Phosphorylation site

Function of phosphorylated proteins

HSV-1/2, VZV

UL13

Ser-18, Ser-118 and Ser-121

Activates kinase activity [87]

HSV-1

Us3

Residues 405 to 481

Not reported

VZV

gE

Residues 590 to 602

Induces viral release and cell-to-cell spread [172]

HSV-1, VZV

ICP22(IE63)

Not detected

Stabilizes or increases the transcription of a specific subset of viral RNAs [43]

HSV-1

ICP0

Ser-224, Thr-226, Thr-232, Thr-232, Ser-365, Ser-367, Ser-371, Ser-508, Ser-514, Ser-517 and Thr-518

Affects the subcellular and subnuclear localization of ICP0; shows trans-activating activity and immune escape [110]

HSV-1

UL41(VHS)

Not detected

Table 1

HSV-1

UL46(VP11/12)

Not detected

Table 1

HSV-1/2, VZV

UL49(VP22)

Not detected

Table 1