From: Regulation of alphaherpesvirus protein via post-translational phosphorylation
Alphaherpesvirus | Phosphorylated protein | Phosphorylation site | Function of phosphorylated proteins |
---|---|---|---|
HSV-1/2, VZV | UL13 | Ser-18, Ser-118 and Ser-121 | Activates kinase activity [87] |
HSV-1 | Us3 | Residues 405 to 481 | Not reported |
VZV | gE | Residues 590 to 602 | Induces viral release and cell-to-cell spread [172] |
HSV-1, VZV | ICP22(IE63) | Not detected | Stabilizes or increases the transcription of a specific subset of viral RNAs [43] |
HSV-1 | ICP0 | Ser-224, Thr-226, Thr-232, Thr-232, Ser-365, Ser-367, Ser-371, Ser-508, Ser-514, Ser-517 and Thr-518 | Affects the subcellular and subnuclear localization of ICP0; shows trans-activating activity and immune escape [110] |
HSV-1 | UL41(VHS) | Not detected | Table 1 |
HSV-1 | UL46(VP11/12) | Not detected | Table 1 |
HSV-1/2, VZV | UL49(VP22) | Not detected | Table 1 |