From: Regulation of alphaherpesvirus protein via post-translational phosphorylation
Alphaherpesvirus | Phosphorylated protein | Phosphorylation site | Functions regulated by phosphorylation |
---|---|---|---|
HSV-1/2, PRV, DPV, MDV-1 | Us3 | Ser-147 | Activates kinase activity; promotes HSK development and virus replication [73] |
HSV-1 | gB | Thr-887 | |
HSV-1 | Us8A | Ser-61 | |
HSV-2 | UL7 | Not detected | Induces virus replication and pathogenicity [166] |
HSV-1 | UL12 | Tyr-371, Thr-474 and Ser-604 | Regulates exonuclease activity, viral replication, neurovirulence [30, 31, 119] |
HSV-1 | UL31 | Ser-11, Ser-24, Ser-26, Ser-27, Ser-40, and/or Ser-43 [92] | |
HSV-1 | UL34 | Thr-195, Ser-198 | Not reported |
HSV-1 | UL41 (VHS) | Not detected | Degrade host mRNAs, shut down host protein synthesis; induce viral replication and regulation of the PKR-mediated immune response [171] |
HSV-1 | UL46 (VP11/12) | Not detected | Induces expression of viral genes, interacts with other proteins and viral progeny s [178, 180] |
HSV-1, BoHV-1 | UL47 | Ser-77,Ser-88 and Thr-685 | Induces viral DNA encapsulation and secondary envelopment [33] and nuclear localization [71, 136] |
BoHV-1 | UL49(VP22) | Not detected | |
HSV-1 | UL51 | Ser-184 | Induces viral replication and virulence [34] |
VZV | IE62 | Ser-686, Ser-722 |