Figure 1

Historical development of resistance of S. suis to different antibiotic classes in A Europe, B Asia, and C America (North and South America). The graphs include data reported between 1987 and 2021 in scientific articles published in National Library of Medicine under search criterium ¨antimicrobial resistance and Streptococcus suis¨, and the antibiotic surveillance data from Denmark (DANMAP) and France (RESAPATH). For panel A, a total of 19 articles and 18 reports (DANMAP, RESAPATH) were used, and totals of 13 and 8 articles were used for panels B and C, respectively. For simplicity, the averages of the percentage of resistance to antibiotics of the same class were calculated for each report. Please note that not all the surveillance systems are using the same Epidemiological cut-off value ECOFFs; we followed the criteria used by authors. The evolution of the multidrug-resistance rate worldwide is depicted in D, taking into consideration a total of 20 scientific articles. Multiresistance was considered when an isolate was resistant to at least three antibiotics of different classes as declared by authors. Also, the average of the antimicrobial-resistance rate of different reports in the same year was used. The X-axes show the year of isolation.