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Table 2 Inhibitory activity of Toosendanin (TSN) in Marc-145 cells infected by different PRRSV strains

From: Toosendanin activates caspase-1 and induces maturation of IL-1β to inhibit type 2 porcine reproductive and respiratory syndrome virus replication via an IFI16-dependent pathway

  PRRSV Strain
NADC30-like VR-2332 CH-1a
EC50 (μM)a 0.20 ± 0.01 0.18 ± 0.01 0.16 ± 0.01
Selectivity index (SI)b 211 235 264
  1. Data were presented as means ± SD of results from three independent experiments
  2. aEC50, the concentration required to protect 50% cells from PRRSV infection by counting infected cells from IFA images, as described in the methods
  3. bSI (selectivity index) is the ratio of CC50 to EC50. CC50 of TSN on Marc-145 cells was 42.32 µM