Figure 4

Innate immune response and acute phase proteins induced by FMDV in African buffalo. Concentrations of SAA (A), hatoglobin (B), type I/III IFN (C) and IFNɣ (D) in serum from animals infected with SAT1, SAT2 or SAT3 FMDV serotypes by NI (blue lines, round symbol) or contact challenge (pink lines, square symbol). Graphs represent the mean and SEM for each group at each time point. Cut-offs for SAA and hatoglobin were established at 546 and 802 ng/µL and cut off for type I IFN and IFNɣ was established at 0.76 iu/mL and 1.04 ng/mL, respectively.