Figure 3From: Evaluation of immunogenicity and cross-reactive responses of vaccines prepared from two chimeric serotype O foot-and-mouth disease viruses in pigs and cattleElectron microscopy of FMDVs. The mutant viruses and the wt virus (fifth passage) were cultured in adherent BHK-21 cells and harvested after the occurrence of 100% CPE. The virus particles were isolated by sucrose density gradient centrifugation and observed by negative-stain electron microscopy. A rHN/NXVP1, B rHN/TURVP1, C rHN. Bar = 100 nm.Back to article page