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Table 2 Protection against B. ovis PA-KmR in mice.

From: A Brucella melitensis H38ΔwbkF rough mutant protects against Brucella ovis in rams

Experiment

Vaccine (CFU dose)

B. ovis PA-KmR (mean ± SD of log10 CFU/spleen)

Units of protectiona

1

Bov::CAΔwadB (108)

2.46 ± 1.68b,c

3.6

 

H38ΔwbkF (108)

3.42 ± 0.62b,c

2.6

 

Rev 1 (105)

2.50 ± 1.49b

3.5

 

Placebo (BSS)

6.04 ± 0.46

0

2

Rev1::wbdRΔwbkC (108)

2.16 ± 0.95b,c

4.1

 

Rev 1 (105)

2.45 ± 1.35b

3.8

 

Placebo (BSS)

6.26 ± 0.16

0

  1. aUnits of protection: average log10 CFU of challenge strain in the spleens of placebo (BSS) controls minus average of log10 CFU of the challenge strain in the spleens of vaccinated mice. bSignificant differences (P < 0.01) versus the placebo (BSS) control group (ANOVA and Fisher’s PSLD test); cNo significant differences versus the Rev 1 vaccinated group (ANOVA and Fisher’s PSLD test).
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Veterinary Research

ISSN: 1297-9716