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Figure 3 | Veterinary Research

Figure 3

From: Pathobiology of highly pathogenic H5 avian influenza viruses in naturally infected Galliformes and Anseriformes in France during winter 2015–2016

Figure 3

Histopathological findings and viral antigen detection in H5 HPAIV naturally infected chickens. A Lung, mixed leukocytic interstitial pneumonia. Frequent NP-positive leukocytes and endothelial cells in air capillaries. B Trachea, lamina propria congestion. Frequent NP-positive cells in endothelial cells. C Spleen, lymphocytolysis, single cell necrosis/apoptosis and mixed leukocytic infiltration. Frequent NP-positive leukocytes. D Intestine, lamina propria single cells necrosis/apoptosis, lymphocytolysis. Frequent NP-positive endothelial cells, leukocytes, epithelial lining and necrotic cell. E Brain, cerebellar foci of lytic necrosis. Abundant viral antigen staining within necrotic debris. F Epicardium, congestivo-edematous epicarditis with lymphocytic and macrophagic infiltration. Frequent NP-positive mesothelial cells. G Proventriculus, acute hemorrhages and congestion at the tip of a proventricular gland close to the primary duct. Frequent NP-positive endothelial cells. H Myocardium, congestion and mild heterophilic infiltration. Rare NP-positive endothelial cells. Hematoxylin and eosin (HE). Anti-nucleoprotein immunohistochemistry (IHC).

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