Figure 3

NLRP3 participates in LPS-induced hepatotoxicity. A Changes in AST activity (a), ALT activity (b), and DBILI content (c) in serum from chickens administered MCC950 (5 mg/kg) followed by exposure to LPS (60 mg/kg). Values are expressed as the mean ± SD for each group (n = 6). **P < 0.01 vs. the control group. ^##P < 0.01 vs. the LPS-treated group. B Histopathological analysis of chicken liver. The images are displayed at 100 × and 400 × the original magnification (scale bar = 50 μm). The experimental groups were the control group (a), LPS-treated group (b), MCC950 + LPS group (c), and MCC950 alone group (d). ALT: alanine aminotransferase; AST: aspartate aminotransferase; DBILI: direct bilirubin.