Skip to main content
Figure 8 | Veterinary Research

Figure 8

From: Prototheca spp. induce an inflammatory response via mtROS-mediated activation of NF-κB and NLRP3 inflammasome pathways in bovine mammary epithelial cell cultures

Figure 8

The pattern of Prototheca spp. infection induced inflammatory responses through NF-κB and NLRP3 inflammasome pathways in bMECs. Infection of bMECs with P. bovis or P. ciferrii, increased mtROS, which can promote activation of NF-κB and NLRP3 inflammasome pathways and further enhance production of IL-β, resulting in an inflammatory response in bMECs. However, in bMECs treated with mito-TEMPO, which scavenged mtROS, protein expression in NF-κB and NLRP3 inflammasome pathways was inhibited and there was suppression of the inflammatory response in P. bovis- or P. ciferrii-infected bMECs.

Back to article page

Veterinary Research

ISSN: 1297-9716