Sertraline as a new potential anthelmintic against Haemonchus contortus: toxicity, efficacy, and biotransformation

Table 2 List of the main metabolites, SRT and D3-SRT detected in samples of H. contortus with their retention times (t_R) from LC–MS and LC-HRMS, m/z of precursor and product ions detected by LC-HRMS, elemental composition and designation

Compound	Elemental composition	t_R LC–MS [min]	t_R LC-HRMS [min]	m/z precursor ions [M + H]⁺	m/z product ions [M + H]⁺	Designation
Hydroxy-SRT	C₁₇H₁₇Cl₂NO	3.74 4.04	10.49 ¹ 11.36 ²	322.0760	304.0661 ² 291.0338¹ 273.0233 ^{1, 2} 238.0542 ^{1, 2}	SRT-OH
SRT-O-glucoside	C₂₃H₂₇Cl₂NO₆	3.14 3.57	9.54 ¹ 10.65 ²	484.1285	273.0232 ^{1, 2} 194.1024 ^{1, 2} 176.0918 ^{1, 2}	SRT-O-GLC
Dihydroxy-SRT	C₁₇H₁₇Cl₂NO₂	3.18 3.34	9.74 ¹ 10.02 ²	338.0717	320.0599 ¹ 289.0185 ^{1, 2} 261.0230 ^{1, 2} 247.0077 ^{1, 2}	SRT-2OH
SRT-ketone	C₁₆H₁₄Cl₂O	3.51	10.48	291.0338	273.0233 238.0543 145.0649	SRT=O
SRT	C₁₇H₁₇Cl₂N	4.29	12.13	306.0810	275.0387 158.9762 129.0699 91.0548
D3-SRT (IS)	C₁₇H₁₇Cl₂N	4.29	12.13	309.0991	275.0394 158.9766 129.0699 91.0548

ISSN: 1297-9716