Table 2 Linear mixed regression models for IL-6, IFN-γ and IL-10 in dry period and early lactation.

IL-6 (pg/mL)

Quarter inoculation status

0.04^d

NS^d,e

 Non-inoculated

Ref.^f

–

133.46

–

Ref.

–

34.37

–

 Inoculated and non-colonized

−58.50

17.98

74.96

0.05

−10.90

10.39

23.47

NS

 Inoculated and colonized

−75.44

17.49

58.02

0.03

−8.82

10.40

25.55

NS

Time of sampling^h

 <0.01^d

–

 D-1

Ref.

–

0.00

–

–

–

–

–

 D14

109.38

7.37

102.49

 <0.01

–

–

–

–

 D27

140.00

7.52

133.11

 <0.01

–

–

–

–

 D41

133.42

7.97

126.54

 <0.01

–

–

–

–

Time of sampling

–

 <0.01^d

 C

–

–

–

–

Ref.

–

110.30

–

 L1

–

–

–

–

−32.89

6.45

77.41

 <0.01

 L2

–

–

–

–

−83.81

7.67

26.49

 <0.01

 L3

–

–

–

–

−108.58

8.09

1.72

 <0.01

 L4

–

–

–

–

−117.24

8.22

−6.94

 <0.01

 L5

–

–

–

–

−117.35

8.18

−7.05

 <0.01

 L6

–

–

–

–

−117.64

7.80

−7.34

 <0.01

Inoculation status × Time of sampling^g

–

–

–

 <0.01^d

–

–

–

 <0.01^d

IFN-γ (pg/mL)

Quarter inoculation status

NS^d

NS^d

 Non-inoculated

Ref.

–

0.00

–

Ref.

–

0.32

–

 Inoculated and non-colonized

0.64

0.24

0.64

0.09

0.41

0.21

0.73

0.06

 Inoculated and colonized

0.83

0.22

0.83

0.06

0.19

0.21

0.52

NS

Time of sampling

 <0.01^d

–

 D-1

Ref.

–

0.00

–

–

–

–

–

 D14

0.21

0.14

0.21

NS

–

–

–

–

 D27

0.46

0.15

0.46

 <0.01

–

–

–

–

 D41

1.28

0.16

1.28

 <0.01

–

–

–

–

Time of sampling

–

 <0.01^d

 C

–

–

–

–

Ref.

–

1.43

–

 L1

–

–

–

–

−0.27

0.20

1.15

NS

 L2

–

–

–

–

−0.91

0.23

0.52

 <0.01

 L3

–

–

–

–

−1.25

0.23

0.18

 <0.01

 L4

–

–

–

–

−1.36

0.23

0.06

 <0.01

 L5

–

–

–

–

−1.31

0.23

0.11

 <0.01

 L6

–

–

–

–

−1.21

0.22

0.21

 <0.01

Inoculation status × Time of sampling^g

–

–

–

 <0.01^d

–

–

–

 <0.01^d

IL-10 (pg/mL)

Quarter inoculation status

 <0.01^d

NS^d

 Non-inoculated

Ref.

–

4559.23

–

Ref.

–

1361.63

–

 Inoculated and non-colonized

−2618.91

336.24

1940.32

 <0.01

−874.42

572.75

487.21

NS

 Inoculated and colonized

−1965.67

303.55

2593.56

 <0.01

−761.25

573.07

600.38

NS

Time of sampling

 <0.01^d

–

 D-1

Ref.

–

0.00

–

–

–

–

–

 D14

3832.82

264.36

3740.15

 <0.01

–

–

–

–

 D27

4228.92

285.91

4136.26

 <0.01

–

–

–

–

 D41

4433.06

287.82

4340.40

 <0.01

–

–

–

–

Time of sampling

–

 <0.01^d

 C

–

–

–

–

Ref.

–

2499.53

–

 L1

–

–

–

–

103.34

218.62

2602.87

NS

 L2

–

–

–

–

−1019.34

262.75

1480.19

 <0.01

 L3

–

–

–

–

−2060.8

278.83

438.73

 <0.01

 L4

–

–

–

–

−3116.52

284.48

−616.99

 <0.01

 L5

–

–

–

–

−2971.28

283.08

−471.75

 <0.01

 L6

–

–

–

–

−2717.27

269.54

−217.74

 <0.01

Inoculation status × Time of sampling^g

–

–

–

 <0.01^d

–

–

–

 <0.01^d