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Table 3 Reisolation of the challenge strain from piglets after intranasal challenge with S. suis cps14 strain V3117/2

From: Immunogenicity and protective efficacy of a Streptococcus suis vaccine composed of six conserved immunogens

Immunization Number of piglets positive for the isolation of the challenge strain in an inner organb or in serosa or in joint fluid Number of piglets positive for the isolation of the challenge strain in ≥ 3 inner organsb Number of piglets in which the S. suis challenge straina was isolated from
Tonsil Lungc Serosad Spleen Liver Brain, CSFe Joint fluidf Endocard
Placebo 3/8 2/8 4/8 2/8 1/8 1/8 1/8 2/8 2/8 1/8
Vaccine 3/8 3/8 6/8 1/8 0/8 2/8 1/8 2/8 3/8 2/8
  1. aThe challenge strain was identified by PCR of all isolates and Sanger sequencing of cpsK locus of five representative isolates from animals showing disseminated infections.
  2. bInner organ refers to lung, spleen, liver, brain, CSF or endocard but not the tonsils.
  3. cOne cranial lobe was investigated.
  4. dPleural, peritoneal or pericardial cavity.
  5. eCerebrospinal fluid.
  6. fPunctures of both tarsal and carpal joints were investigated in each animal. In case of lameness additional joint punctures of the respective limb were screened.