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Table 1 Immunogens selected for the multicomponent vaccine

From: Immunogenicity and protective efficacy of a Streptococcus suis vaccine composed of six conserved immunogens

SSU in P1/7 Putative function/ortholog Localisation/tagg PSORTb (score) Theoretical molecular weight (kDa)a Reference
SSU0934 Basic membrane lipoprotein Signal sequenceb Lipobox (LAAC) Unknown 36 [52]
SSU1869 Zinc ABC transporter TroA signal sequenceb Membrane (9.68) 34 [41, 58]
SSU0757 Subtilisin-like serine protease signal sequenceb LPXTG Cell wall (10) 168c [42, 59, 60]
SSU1950 LysM protein signal sequenceb Unknown 19 [43, 61]
SSU1664 Oligopeptide substrate-binding protein OppA Signal sequenceb Lipobox (LAAC) Unknown 64 [44, 45]
SSU0187 Di-peptidyl peptidase IV No signal sequenceb Extracellular (9.6) 88 [62, 63]
  1. aExcluding posttranslational modifications.
  2. bDetection by SignalP3.0 (using neural networks (NN) and hidden Markov models (HMM) trained on Gram-positive bacteria).
  3. cIn strain 16085/3b an early stop codon within an insertion results in an ORF of only 40 kDa and without an LPXTG motif.