Immunogenicity and protective efficacy of a Streptococcus suis vaccine composed of six conserved immunogens

Table 1 Immunogens selected for the multicomponent vaccine

SSU in P1/7	Putative function/ortholog	Localisation/tagg	PSORTb (score)	Theoretical molecular weight (kDa)^a	Reference
SSU0934	Basic membrane lipoprotein	Signal sequence^b Lipobox (LAAC)	Unknown	36	[52]
SSU1869	Zinc ABC transporter TroA	signal sequence^b	Membrane (9.68)	34	[41, 58]
SSU0757	Subtilisin-like serine protease	signal sequence^b LPXTG	Cell wall (10)	168^c	[42, 59, 60]
SSU1950	LysM protein	signal sequence^b	Unknown	19	[43, 61]
SSU1664	Oligopeptide substrate-binding protein OppA	Signal sequence^b Lipobox (LAAC)	Unknown	64	[44, 45]
SSU0187	Di-peptidyl peptidase IV	No signal sequence^b	Extracellular (9.6)	88	[62, 63]

^aExcluding posttranslational modifications.
^bDetection by SignalP3.0 (using neural networks (NN) and hidden Markov models (HMM) trained on Gram-positive bacteria).
^cIn strain 16085/3b an early stop codon within an insertion results in an ORF of only 40 kDa and without an LPXTG motif.

ISSN: 1297-9716