Figure 3

Immunization elicited significant higher titers of IgG against all six immunogens included in the vaccine. Serum was collected before prime immunization and eleven days after booster immunization with a multicomponent vaccine (n = 8) or a placebo (n = 8). Each serum was incubated with beads coupled with selected antigens. Detection of bound serum IgG was performed using the xMAPr approach [23]. Paired Wilcoxon rank sum test (black), unpaired Wilcoxon rank sum test (brown), red star indicates imputed value. p-value: ≤ 0.001 = ***; ≤ 0.01 = **; ≤ 0.05 = *; > 0.05 = NS.