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Figure 4 | Veterinary Research

Figure 4

From: Ferulic acid inhibits LPS-induced apoptosis in bovine mammary epithelial cells by regulating the NF-κB and Nrf2 signalling pathways to restore mitochondrial dynamics and ROS generation

Figure 4

FA effectively rebalanced the redox state of BMECs that was disturbed by LPS. Cells were stimulated with LPS (50 μg/mL) for 12 h after a 2 h incubation with the indicated concentrations (0, 5, 10, or 15 μg/mL) of FA diluted in serum-free medium. Cell contents and total RNA were extracted and prepared. The activities of SOD and GSH-Px and the MDA content were detected using commercial kits. COX2 expression was detected using RT-qPCR. The data are presented as means ± SEM (n = 3). ###P < 0.001 compared with the control group, *P < 0.05 compared with the LPS group, **P < 0.01 compared with the LPS group, and ***P < 0.001 compared with the LPS group.

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Veterinary Research

ISSN: 1297-9716