Cellular and humoral immune responses associated with protection in sheep vaccinated against Teladorsagia circumcincta

Table 2 Levels of serum immunoglobulins against extracts of the fourth larval stage (L4) of Teladorsagia circumcincta in Canaria Sheep (CS) and Canaria Hair Breed (CHB) sheep vaccinated with a prototype recombinant sub-unit T. circumcincta vaccine and subsequently challenged with T. circumcincta

Isotype	Group	Mean ± SEM	Cumulative FEC	Worm burden	Worm length	EIU
Correlation
IgA	CS	1.189 ± 0.054	−0.223	0.016	−0.333	−0.267
	CS Vac	1.160 ± 0.066	−0.371	−0.545	−0.776**	−0.615*
	CS Con	1.220 ± 0.089	0.027	0.542	−0.023	0.255
	CHB	1.335 ± 0.073	−0.077	−0.335	0.065	−0.007
	CHB Vac	1.509 ± 0.124**	− 0.545	−0.600	0.042	−0.212
	CHB Con	1.175 ± 0.055**	0.263	0.259	0.203	0.224
IgG1	CS	1.547 ± 0.057	−0.033	0.191	0.050	0.120
	CS Vac	1.508 ± 0.151	0.224	0.084	−0.238	−0.182
	CS Con	1.590 ± 0.145	−0.164	0.436	0.164	0.564
	CHB	1.305 ± 0.103	0.107	−0.179	0.259	0.234
	CHB Vac	1.312 ± 0.063	−0.227	−0.191	0.261	0.261
	CHB Con	1.300 ± 0.095	0.305	−0.042	0.196	0.245
IgG2	CS	1.241 ± 0.047	−0.158	0.037	−0.190	−0.239
	CS Vac	1.234 ± 0.070	−0.594*	−0.594*	−0.867**	−0.825**
	CS Con	1.249 ± 0.064	0.227	0.782**	0.291	0.473
	CHB	1.205 ± 0.050	0.345	0.012	0.448*	0.655**
	CHB Vac	1.255 ± 0.092	0.327	0.073	0.406	0.733*
	CHB Con	1.160 ± 0.046	0.261	0.042	0.483	0.578*

Antibody levels are expressed as optical density index (ODI) value + 1 (ODI + 1). Associations are expressed as Spearman’s correlation coefficient. Statistically-significant differences within breeds for a specific isotype and antigen and significant correlations are represented with “*” at p < 0.05 and “**” at p < 0.01.

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