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Table 2 Levels of serum immunoglobulins against extracts of the fourth larval stage (L4) of Teladorsagia circumcincta in Canaria Sheep (CS) and Canaria Hair Breed (CHB) sheep vaccinated with a prototype recombinant sub-unit T. circumcincta vaccine and subsequently challenged with T. circumcincta

From: Cellular and humoral immune responses associated with protection in sheep vaccinated against Teladorsagia circumcincta

Isotype Group Mean ± SEM Cumulative FEC Worm burden Worm length EIU
Correlation
 IgA CS 1.189 ± 0.054 −0.223 0.016 −0.333 −0.267
CS Vac 1.160 ± 0.066 −0.371 −0.545 −0.776** −0.615*
CS Con 1.220 ± 0.089 0.027 0.542 −0.023 0.255
CHB 1.335 ± 0.073 −0.077 −0.335 0.065 −0.007
CHB Vac 1.509 ± 0.124** − 0.545 −0.600 0.042 −0.212
CHB Con 1.175 ± 0.055** 0.263 0.259 0.203 0.224
 IgG1 CS 1.547 ± 0.057 −0.033 0.191 0.050 0.120
CS Vac 1.508 ± 0.151 0.224 0.084 −0.238 −0.182
CS Con 1.590 ± 0.145 −0.164 0.436 0.164 0.564
CHB 1.305 ± 0.103 0.107 −0.179 0.259 0.234
CHB Vac 1.312 ± 0.063 −0.227 −0.191 0.261 0.261
CHB Con 1.300 ± 0.095 0.305 −0.042 0.196 0.245
 IgG2 CS 1.241 ± 0.047 −0.158 0.037 −0.190 −0.239
CS Vac 1.234 ± 0.070 −0.594* −0.594* −0.867** −0.825**
CS Con 1.249 ± 0.064 0.227 0.782** 0.291 0.473
CHB 1.205 ± 0.050 0.345 0.012 0.448* 0.655**
CHB Vac 1.255 ± 0.092 0.327 0.073 0.406 0.733*
CHB Con 1.160 ± 0.046 0.261 0.042 0.483 0.578*
  1. Antibody levels are expressed as optical density index (ODI) value + 1 (ODI + 1). Associations are expressed as Spearman’s correlation coefficient. Statistically-significant differences within breeds for a specific isotype and antigen and significant correlations are represented with “*” at p < 0.05 and “**” at p < 0.01.