Figure 1

The phylogenetic tree based on the full‐length spike gene of PEDVs isolated in China during 2007–2019 (continue on Additional file 1). Multiple-sequence alignments were performed using Clustal Omega server and the phylogenetic tree was constructed from the aligned nucleotide sequences by using the neighbor-joining method in the MEGA-X software [59, 60]. The numbers at each branch represent bootstrap values greater than 70% of 1000 replicates. The scale bars indicate the number of 0.005 inferred substitutions per site. 4 more PEDV strains including virulent CV777 (AF353511.1), virulent DR13 (JQ023161.1), attenuated CV777 (KT323979), and attenuated DR13 (JQ023162.1) were also included as references. The blue squares indicate the virulent strains isolated outside of China. The red triangles indicate the cell culture-adapted vaccine strains or the pandemic strains used to make vaccines. The green upside-down triangles indicate the GI-c viral isolates.