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Figure 11 | Veterinary Research

Figure 11

From: A newly identified Hippo homologue from the oriental river prawn Macrobrachium nipponense is involved in the antimicrobial immune response

Figure 11

Schematic representation of Hippo-regulated antimicrobial activities in oriental river prawns. In M. nipponense, Hippo–Yorkie signalling was activated by Gram-positive and Gram-negative bacteria. The activation of this signalling axis excluded Yorkie from the nucleus. Inhibition of the Hippo pathway promoted Yorkie translocation, enabling Cactus transcription; the high expression of Cactus prevented the transfer of Dorsal/Dif from the cytoplasm into the nucleus, thereby reducing the expression of AMPs (such as ALF, crustin, and lysozyme).

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