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Table 2 Protective efficacy conferred by antigen proteins against B. abortus S19 infection

From: Screening of potential vaccine candidates against pathogenic Brucella spp. using compositive reverse vaccinology

Vaccine Group (n = 6) Adjuvanta Log10 CFU (Spleen)b Protection units Log10 CFU (Liver) Protection units
PBS 5.53 ± 0.19 0 5.7 ± 0.26 0
Omp19 FA/IFA/IFA 2.56 ± 0.21 2.97*** 4.41 ± 0.22 1.29***
VirB8 FA/IFA/IFA 3.17 ± 0.49 2.36*** 4.66 ± 0.46 1.04**
HlyD FA/IFA/IFA 4.44 ± 0.15 1.09** 4.93 ± 0.15 0.77*
104 M 3.65 ± 0.35 1.88*** 3.74 ± 0.16 1.96***
  1. Protection units of immunized group is compared with that of PBS control with t-test, p < 0.05 is statistically significant. (*p < 0.05; **p < 0.01; ***p < 0.001)
  2. aAdjuvant: FA, Freund’s adjuvant; IFA, incomplete Freund’s adjuvant.
  3. bCFU, colony-forming units.