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Table 2 Protective efficacy conferred by antigen proteins against B. abortus S19 infection

From: Screening of potential vaccine candidates against pathogenic Brucella spp. using compositive reverse vaccinology

Vaccine Group (n = 6)

Adjuvanta

Log10 CFU (Spleen)b

Protection units

Log10 CFU (Liver)

Protection units

PBS

–

5.53 ± 0.19

0

5.7 ± 0.26

0

Omp19

FA/IFA/IFA

2.56 ± 0.21

2.97***

4.41 ± 0.22

1.29***

VirB8

FA/IFA/IFA

3.17 ± 0.49

2.36***

4.66 ± 0.46

1.04**

HlyD

FA/IFA/IFA

4.44 ± 0.15

1.09**

4.93 ± 0.15

0.77*

104 M

–

3.65 ± 0.35

1.88***

3.74 ± 0.16

1.96***

  1. Protection units of immunized group is compared with that of PBS control with t-test, p < 0.05 is statistically significant. (*p < 0.05; **p < 0.01; ***p < 0.001)
  2. aAdjuvant: FA, Freund’s adjuvant; IFA, incomplete Freund’s adjuvant.
  3. bCFU, colony-forming units.
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Veterinary Research

ISSN: 1297-9716