Skip to main content
Figure 2 | Veterinary Research

Figure 2

From: GSDMD contributes to host defence against Staphylococcus aureus skin infection by suppressing the Cxcl1–Cxcr2 axis

Figure 2

GSDMD deficiency leads to enhanced inflammatory cell infiltration following S. aureus skin infection. WT and GSDMD−/− mice were infected s.c. with 1 × 107 CFU S. aureus, and abscess tissue was excised on day 2 post-infection. Representative immunohistochemical staining of A F4/80 (a macrophagocyte marker) and B Gr-1 (a neutrophil marker) was performed in the skin sections. C The homogenate supernatants of skins were also used to determine the activity of MPO (a neutrophil marker). The data are shown as the mean ± SEM. n = 9 per group. Data were pooled from 2 independent experiments. Student’s t-test was performed. Statistical significance is indicated by *p < 0.05, **p < 0.01, and ***p < 0.001.

Back to article page