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Table 1 Influence of tonB123 deletion on the susceptibility of A. hydrophila strains to macrolide

From: The TonB system in Aeromonas hydrophila NJ-35 is essential for MacA2B2 efflux pump-mediated macrolide resistance

Strain MIC (mg/L)
ROX ERY TIL TYL ACE AZI DIR MED
WT 32 16 64 128 256 1 128 128
ΔtonB123 2 1 4 16 16 0.125 16 8
ΔtonB123 + ptonB1 16 8 32 64 64 1 64 128
ΔtonB123 + ptonB2 16 8 32 64 64 1 64 128
ΔtonB123 + ptonB3 8 4 16 32 32 0.25 64 64
ΔmacA1B1 32 16 64 128 256 1 128 128
ΔtonB123ΔmacA1B1 2 1 4 16 16 0.125 16 8
ΔmacA2B2 2 1 4 16 16 0.125 16 8
ΔtonB123ΔmacA2B2 2 1 4 16 16 0.125 16 8
ΔmacA2B2 + pmacA2B2 32 16 64 128 256 1 128 128
ΔtonB123ΔmacA2B2 + pmacA2B2 2 1 4 16 16 0.125 16 8
  1. ROX: roxithromycin, ERY: erythromycin, TIL: tilmicosin, TYL: tylosin, ACE: acetylspiramycin, AZI: azithromycin, DIR: dirithromycin, MED: medemycin.