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Table 3 Final linear mixed regression model for the β-galactosidase liquid assay for rnaIII gene expression and final model corrected for in vitro growth inhibition of Staphylococcus aureus by bovine non-aureus staphylococci (NAS)

From: Metabolites of bovine-associated non-aureus staphylococci influence expression of Staphylococcus aureus agr-related genes in vitro

Predictor variables

Final model

Final model corrected for in vitro growth inhibition

β1

SE2

LSM3

p value4

β

SE

LSM

p value

Intercept

1.42

0.05

–

 

1.53

0.10

–

 

Time of measurement

   

< 0.0001

   

 < 0.0001

 1 h

Referent

–

28.46

 

Referent

–

26.45

 

 2 h

0.15

0.03

43.24

 

0.15

0.03

40.20

 

 3 h

−0.005

0.04

43.79

 

−0.005

0.04

40.70

 

 4 h

0.03

0.05

47.65

 

0.03

0.05

44.30

 

NAS species

   

0.0002

   

0.0275

 S. aureus + S. chromogenes

0.06

0.06

36.20

 

0.07

0.06

35.65

 

 S. aureus + S. epidermidis

0.04

0.08

60.63

 

–0.04

0.10

50.41

 

 S. aureus + S. simulans

Referent

–

29.22

 

Referent

–

28.67

 

Habitat

   

NS5

    

 Milk

–

–

–

–

    

 Teat apex

–

–

–

–

    

In vitro growth inhibition6

   

NS

   

(0.2957)8

 None

–

–

–

–

Referent

–

48.76

 

 Partial

–

–

–

–

−0.11

0.10

38.14

 

 Total

–

–

–

–

−0.25

0.16

27.70

 

NAS species × Time of measurement7

   

< 0.0001

   

< 0.0001

NAS species × Habitat

–

–

–

NS

   

–

NAS species × In vitro growth inhibition

–

–

–

NS

   

–

Habitat × In vitro growth inhibition

–

–

–

NS

   

–

Habitat × Time of measurement

–

–

–

NS

   

–

  1. 1Estimate.
  2. 2Standard error.
  3. 3Least square means after back transformation.
  4. 4Overall P value for fixed effects.
  5. 5Non-significant.
  6. 6See Materials and methods.
  7. 7The interaction term is visualized in Figure 2B.
  8. 8Forced into the model.