Classical scrapie in small ruminants is caused by at least four different prion strains

Table 3 Classical scrapie classification of the isolates included in this study.

Category	Isolate ID (origin species)	Characteristics in TgGoat-ARQ		Characteristics in TgBov
Category	Isolate ID (origin species)	Mean survival time^a	PrP^res signature	Mean survival time^a	PrP^res signature
I^b	I2 (Goat)	Slow	21 kDa	Fast	21 kDa
	I3 (Goat)
	I9 (Goat)
	198-9 (Sheep)
II^c	F2 (Goat)	Fast	21 kDa	Fast	19 kDa
	F3 (Goat)
	F6 (Goat)
	N3-fast (Goat)
	S2 (Goat)
	S3 (Goat)
	PS21 (Sheep)
	Langlade (Sheep)
	PS09 (Sheep)
III^c	UKB2 (Goat)	Fast	19 kDa	Fast
	08-8309 (Sheep)
	08-27433 (Sheep)
	CH1641 (Sheep)
IV	G2 (Goat)	Slow	21 kDa	Slow	19 kDa
	G3 (Goat)
	N1 (Goat)
	N3-slow (Goat)
	C1 (Goat)
	C2 (Goat)
	PS83 (Sheep)

^aMean survival times greater than 300 dpi were considered slow, while mean survival times less than 300 dpi were considered fast
^bGoat isolate F16 showed some features compatible with classification in group I, but more data are needed to further determine whether one or more strains are present in this isolate
^cGoat isolate UKA2 showed some features compatible with classification in groups II and III, but more data are needed to further determine whether one or more strains are present in this isolate

ISSN: 1297-9716